Skip to main content

Table 2 Stasis Box lead molecules

From: Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

MMV ID CHEMBL ID Name(s) Indication Mechanism of action Target
MMV690732 CHEMBL3545403 XL-139;
BMS-833923
Cancer Smoothened homolog antagonist Smoothened homolog
MMV690596 CHEMBL1836102 CGP-71683 Obesity, eating disorder Neuropeptide receptor antagonist na
MMV003452 CHEMBL15928 GR-127935 Depression 5-HT 1B/1D receptor antagonist 5-HT 1B and 5-HT 1D receptors
MMV690599 CHEMBL88272 RS-17053 Prostate hyperplasia Alpha 1 adrenoreceptor antagonist na
MMV690466 CHEMBL59030 GW-3965 Inflammation, melanoma Agonist of LXR receptor na
MMV690787 CHEMBL513909 BI-2536 Cancer Serine/threonine-protein kinase PLK1 inhibitor Serine/threonine-protein kinase PLK1
MMV690684 CHEMBL91867 CL-387785 Cancer Epidermal growth factor receptor (EGFR) receptor antagonist + Tyrosine Kinase (TK) inhibitor na
MMV690646 CHEMBL2111096 CK0238273;
SB-715992-S; Ispinesib
Cancer Kinesin inhibitor KIF11
MMV690765 CHEMBL607707 EKB-569;
Pelitinib
Cancer EGFR erbB1 inhibitor EGFR erbB1
MMV690534 CHEMBL238125 SD-208 Cancer, chronic pulmonary obstruction TGFb TK inhibitor + receptor antagonist na
MMV001539 CHEMBL16687 CGS-15943 Ischemia, stroke Adenosine A2 receptor antagonist na
  1. Abbreviation: na not available