Table 3 IC₅₀ values on NTS and adult S. mansoni, toxicity on L6 and MRC5-cells and selectivity of the 11 Stasis Box lead molecules. Cytotoxic concentration (CC₅₀) and selectivity index (SI) are compared to the mean IC₅₀ values measured on NTS and adult S. mansoni in standard and albumin-enriched medium (45 g/l) over 72 h with 11 Stasis Box lead compounds

MMV690732

29.5

6.3

3.5

4.9

2.9

2.5

62.8

181.0

54.1

2.3

0.9

1.9

0.7

MMV690596

1.1

1.3

0.6

1.0

2.1

2.0

27.5

14.4

11.0

3.5

1.7

1.9

0.9

MMV003452

4.4

2.2

1.2

1.7

3.0

2.7

22.6

12.0

7.5

3.7

1.4

1.9

0.7

MMV690599

10.5

3.5

1.5

2.5

3.3

2.6

23.6

19.1

15.9

3.4

1.3

2

0.8

MMV690466

14.6

3.8

2.1

2.9

2.3

2.0

18.1^b

89.7

47.6

1.6

0.8

8.4

4.3

MMV690787

38.4^b

8.1

6.3

7.9

7.2

3.1

39.5

14.4

13.3

na

na

0.1

0

MMV690684

4.0^c

3.1^c

0.7

4.9

4.7

3.7

76.8

14.4^b

7.7

7.0

1.9

7

1.9

MMV690646

3.0^c

1.1

0.9

3.7

2.2

2.2

32.0

121.8

33.6

na

na

0.2

0.1

MMV690765

914.4^b

> 1^c

0.5^b

4.2

3.4

2.9

651.7

225.9^b

123.5^b

11.8

4.1

0.7

0.3

MMV690534

11.8

14.3^c

7.2^c

17.4

19.3

7.5

na

na

na

74.5

15.0

12.4

2.5

MMV001539

12.7

11.0^c

1.7

28.2

12.3

7.0

nd

nd

nd

2.9

0.4

16

2.1