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Table 4 In vivo efficacy of the lead molecules from the Stasis Box. Effect on worm burden of a single 200 mg/kg oral dose of nine lead molecules identified after screening the Stasis Box in vitro administered to mice harbouring a 49-day-old adult S. mansoni infection

From: Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

Compound Mice testedn Mean worm burden ± SD WBR (%)
MMV690732 41 47.5 ± 24.3 0
MMV690599 31 44.7 ± 29.6 3.2
MMV690787 41 48.3 ± 21.6 0
MMV003452 41 40.5 ± 17.2 12.2
MMV690596 41 52.0 ± 22.7 0
MMV690684 41 41.5 ± 16.5 10.0
MMV690765 31 84.0 ± 56.4 0
MMV690466 42 10.3 ± 6.9 35.9
MMV690534 42 7.8 ± 7.5 51.6
Control1 8 46.1 ± 21.9  
Control2 2 16.0 ± 19.8  
  1. n Indicates the mice control batch. One mouse died prematurely because of toxic effects of MMV690646 (Ispinesib) and therefore data is not shown