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Table 4 In vivo efficacy of the lead molecules from the Stasis Box. Effect on worm burden of a single 200 mg/kg oral dose of nine lead molecules identified after screening the Stasis Box in vitro administered to mice harbouring a 49-day-old adult S. mansoni infection

From: Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

Compound

Mice testedn

Mean worm burden ± SD

WBR (%)

MMV690732

41

47.5 ± 24.3

0

MMV690599

31

44.7 ± 29.6

3.2

MMV690787

41

48.3 ± 21.6

0

MMV003452

41

40.5 ± 17.2

12.2

MMV690596

41

52.0 ± 22.7

0

MMV690684

41

41.5 ± 16.5

10.0

MMV690765

31

84.0 ± 56.4

0

MMV690466

42

10.3 ± 6.9

35.9

MMV690534

42

7.8 ± 7.5

51.6

Control1

8

46.1 ± 21.9

 

Control2

2

16.0 ± 19.8

 
  1. n Indicates the mice control batch. One mouse died prematurely because of toxic effects of MMV690646 (Ispinesib) and therefore data is not shown