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Table 1 Flea-control efficacy fluralaner-treated dogs compared to sham-treated controls in a simulated home environment

From: A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment

Days pre/post-treatment

Mean flea count (arithmetic/geometric)

% Efficacy (arithmetic/geometric)

t ( df)

P

Control groupa

Fluralaner groupa

-1

41.6/24.2 (10/10)

19.4/10.4 (8/10)

na

  

1

4.4/2.9 (8/10)

*0.2/0.1 (1/10)

95.5/96.0

t(9.0) = -4.198

0.002

7

5.2/4.0 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -7.425

< 0.0001

14

4.0/2.5 (9/10)

**0.3/0.1 (1/10)

92.5/94.1

t(18.0) = -3.740

0.001

21

26.7/12.6 (8/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -4.947

0.001

28

27.8/19.9 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -9.925

< 0.0001

35

31.8/30.3 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -33.26

< 0.0001

42

17.7/15.0 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -15.80

< 0.0001

49

34.8/32.8 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -30.95

< 0.0001

56

47.5/40.2 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -18.43

< 0.0001

63

21.9/15.4 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -10.72

< 0.0001

70

12.3/8.9 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -10.49

< 0.0001

77

40.4/37.7 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -32.10

< 0.0001

84

58.0/52.8 (10/10)

**0.0/0.0 (0/10)

100/100

t(9.0) = -28.25

< 0.0001

  1. Abbreviations: df degrees of freedom, na not applicable (pre-treatment)
  2. aNumber infested/total number in group
  3. Significantly different from control group: *P = 0.002, **P ≤ 0.001