Fig. 3

CHIKV suppresses DENV replication in cell culture assays. a Confluent monolayers of HMEC-1 cells were infected in triplicate, with a single virus at 2.5 MOIs (CHIKV, DENV1 or DENV-2) or co-infected with CHIKV-DENV-1 or CHIKV-DENV-2 Viral titers for DENV-1 and CHIKV mono-infection assays, DENV-1 titers for co-infected cells (Co-DENV-1) and CHIKV titers for co-infected cells (Co-CHIKV). b Viral titers for DENV-2 and CHIKV mono-infection assays), DENV-2 titers for co-infected cells (Co-DENV-2) and CHIKV titers for co-infected cells (Co-CHIKV). Viral titers were measured at indicated time points. The data shown represent the averages from at least 3 independent experiments. Standard deviations of the means are shown. Statistical significance was determined with Student’s t-tests