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Table 4 Mean values ± standard deviation (M ± SD) of haematological parameters recorded in dogs during the study. Dogs were treated with Frontline Tri-Act and Nexgard Spectra on study Day 0 and thereafter every 28 (± 2 days) up to Day 140

From: Six-month field efficacy and safety of the combined treatment of dogs with Frontline Tri-Act® and NexGard Spectra®

Parameters

RRa

Study days

P-value

Day -7

Day 28

Day 84

Day 168

M ± SD

M ± SD

M ± SD

M ± SD

RBC

5.5–8.5 × 106/μl

6.8 ± 0.9

7.0 ± 0.8

7.2 ± 0.7

7.1 ± 0.4

0.12

WBC

6–17 × 103/μl

12.9 ± 2.9

12.0 ± 2.5

12.1 ± 2.3

11.9 ± 12.6

0.07

HCT

39–56%

42.2 ± 6.2

43.3 ± 4.8

46.2 ± 4.4*

52.4 ± 4.2*

< 0.001

HGB

11–19 g/dl

14.3 ± 2.2

14.42 ± 1.5

14.9 ± 1.4

18.3 ± 2.2*

< 0.001

PLT

117–460 × 103/μl

231.6 ± 84.1

233.6 ± 75.3

244.1 ± 96.7

284.8 ± 108.2*

< 0.05

  1. Abbreviations: RBC Red blood cells, WBC white blood cells, HCT haematocrit, HGB haemoglobin, PLT platelets count
  2. *Statistically significant different vs Day -7
  3. aReference range [36]