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Table 4 Mean values ± standard deviation (M ± SD) of haematological parameters recorded in dogs during the study. Dogs were treated with Frontline Tri-Act and Nexgard Spectra on study Day 0 and thereafter every 28 (± 2 days) up to Day 140

From: Six-month field efficacy and safety of the combined treatment of dogs with Frontline Tri-Act® and NexGard Spectra®

Parameters RRa Study days P-value
Day -7 Day 28 Day 84 Day 168
M ± SD M ± SD M ± SD M ± SD
RBC 5.5–8.5 × 106/μl 6.8 ± 0.9 7.0 ± 0.8 7.2 ± 0.7 7.1 ± 0.4 0.12
WBC 6–17 × 103/μl 12.9 ± 2.9 12.0 ± 2.5 12.1 ± 2.3 11.9 ± 12.6 0.07
HCT 39–56% 42.2 ± 6.2 43.3 ± 4.8 46.2 ± 4.4* 52.4 ± 4.2* < 0.001
HGB 11–19 g/dl 14.3 ± 2.2 14.42 ± 1.5 14.9 ± 1.4 18.3 ± 2.2* < 0.001
PLT 117–460 × 103/μl 231.6 ± 84.1 233.6 ± 75.3 244.1 ± 96.7 284.8 ± 108.2* < 0.05
  1. Abbreviations: RBC Red blood cells, WBC white blood cells, HCT haematocrit, HGB haemoglobin, PLT platelets count
  2. *Statistically significant different vs Day -7
  3. aReference range [36]