Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats

Parasites & Vectors

Table 2 Comparisons between fed and fasted groups following oral administration of lotilaner at 6 mg/kg

Parameter	Ratio (fasted to fed)	90% CI	t-value	P-value^a
T_1/2z	0.806	0.503–1.291	t₍₂₂₎ = -0.79	0.4397
MRT	0.789	0.504–1.234	t₍₂₂₎ = -0.91	0.3730
C_max (dose normalized)	0.108	0.073–0.159	t₍₁₅₎ = -10.05	< 0.0001
AUC_last (dose normalized)	0.080	0.058–0.110	t₍₂₂₎ = -13.44	< 0.0001
AUC_inf (dose normalized)	0.067	0.044–0.100	t₍₂₂₎ = -11.33	< 0.0001
Bioavailability	0.080	0.058–0.110	t₍₂₂₎ = -13.44	< 0.0001

ISSN: 1756-3305