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Table 3 Mean flea counts in control and lotilaner-treated animals and % efficacy at 8 hours post-treatment and 8 hours after weekly infestations (Study 2)

From: Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats

  Number of animals, day of infestation and flea count
n 0 n 7 n 14 n 21 n 28 n 35
Control Arithmetic mean ± SD 8 82.4 ± 8.1 7 79.6 ± 12.7 7 82.7 ± 15.6 6 83.7 ± 7.7 7 85.6 ± 13.5 7 81.6 ± 9.7
Geometric mean 82.0 78.7 81.4 83.4 84.7 81.1
Lotilaner Arithmetic mean ± SD 8 2.1 ± 3.6 8 1.0 ± 1.4 8 1.9 ± 0.1 8 0.1 ± 0.4 8 1.9 ± 1.5 8 6.9 ± 7.1
Efficacy (%) 97.4 98.7 97.7 99.9 97.8 91.6
Geometric mean 1.0 0.7 1.7 0.1 1.5 4.5
Efficacy (%) 98.8 99.2 97.9 99.9 98.3 94.5
Comparison   t(6) = 11.3, P < 0.0001   t(5) =17.9, P < 0.0001   t(5) = 25.0, P < 0.0001   t(4) = 42.7, P < 0.0001   t(5) = 15.4, P < 0.0001   t(5) = 7.3, P = 0.0008
  1. Abbreviation: SD standard deviation