Table 3 Mean flea counts in control and lotilaner-treated animals and % efficacy at 8 hours post-treatment and 8 hours after weekly infestations (Study 2)
Number of animals, day of infestation and flea count | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | 0 | n | 7 | n | 14 | n | 21 | n | 28 | n | 35 | ||
Control | Arithmetic mean ± SD | 8 | 82.4 ± 8.1 | 7 | 79.6 ± 12.7 | 7 | 82.7 ± 15.6 | 6 | 83.7 ± 7.7 | 7 | 85.6 ± 13.5 | 7 | 81.6 ± 9.7 |
Geometric mean | 82.0 | 78.7 | 81.4 | 83.4 | 84.7 | 81.1 | |||||||
Lotilaner | Arithmetic mean ± SD | 8 | 2.1 ± 3.6 | 8 | 1.0 ± 1.4 | 8 | 1.9 ± 0.1 | 8 | 0.1 ± 0.4 | 8 | 1.9 ± 1.5 | 8 | 6.9 ± 7.1 |
Efficacy (%) | 97.4 | 98.7 | 97.7 | 99.9 | 97.8 | 91.6 | |||||||
Geometric mean | 1.0 | 0.7 | 1.7 | 0.1 | 1.5 | 4.5 | |||||||
Efficacy (%) | 98.8 | 99.2 | 97.9 | 99.9 | 98.3 | 94.5 | |||||||
Comparison | t(6) = 11.3, P < 0.0001 | t(5) =17.9, P < 0.0001 | t(5) = 25.0, P < 0.0001 | t(4) = 42.7, P < 0.0001 | t(5) = 15.4, P < 0.0001 | t(5) = 7.3, P = 0.0008 | |||||||