Table 4 Mean flea counts in control and lotilaner-treated animals and % efficacy at 12 hours post-treatment and 12 hours after weekly infestations (Study 2)

Control

Arithmetic mean ± SD

8

69.6 ± 14.4

8

86.9 ± 14.5

8

76.6 ± 11.4

8

85.0 ± 9.7

8

83.1 ± 11.1

8

84.4 ± 5.0

Geometric mean

68.3

85.7

75.9

84.5

82.4

84.2

Lotilaner

Arithmetic mean ± SD

8

1.0 ± 21

7

0.0 ± 0.0

7

0.0 ± 0.0

7

0.0 ± 0.0

7

0.3 ± 0.5

7

1.1 ± 2.3

Efficacy (%)

98.6

100

100

100

99.7

98.6

Geometric mean

0.5

0

0

0

0.2

0.5

Efficacy (%)

99.3

100

100

100

99.7

99.4

t₍₆₎ = 15.5,

P < 0.0001

t₍₅₎ = 66.3,

P < 0.0001

t₍₅₎ = 74.7,

P < 0.0001

t₍₅₎ = 280.6,

P < 0.0001

t₍₅₎ = 39.0,

P < 0.0001

t₍₅₎ = 15.0,

P < 0.0001