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Table 4 Mean flea counts in control and lotilaner-treated animals and % efficacy at 12 hours post-treatment and 12 hours after weekly infestations (Study 2)

From: Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats

  Number of animals, day of infestation and flea count
n 0 n 7 n 14 n 21 n 28 n 35
Control Arithmetic mean ± SD 8 69.6 ± 14.4 8 86.9 ± 14.5 8 76.6 ± 11.4 8 85.0 ± 9.7 8 83.1 ± 11.1 8 84.4 ± 5.0
  Geometric mean 68.3 85.7 75.9 84.5 82.4 84.2
Lotilaner Arithmetic mean ± SD 8 1.0 ± 21 7 0.0 ± 0.0 7 0.0 ± 0.0 7 0.0 ± 0.0 7 0.3 ± 0.5 7 1.1 ± 2.3
  Efficacy (%) 98.6 100 100 100 99.7 98.6
  Geometric mean 0.5 0 0 0 0.2 0.5
  Efficacy (%) 99.3 100 100 100 99.7 99.4
Comparison   t(6) = 15.5,
P < 0.0001
  t(5) = 66.3,
P < 0.0001
  t(5) = 74.7,
P < 0.0001
  t(5) = 280.6,
P < 0.0001
  t(5) = 39.0,
P < 0.0001
  t(5) = 15.0,
P < 0.0001
  1. Abbreviation: SD standard deviation