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Fig. 3 | Parasites & Vectors

Fig. 3

From: Controlled efficacy trial confirming toltrazuril resistance in a field isolate of ovine Eimeria spp.

Fig. 3

Examples of gross pathology and histological findings in lambs infected with Eimeria spp. a, b, d-f were treated lambs, while c was a control. a Section from ileum with multiple, coalescing beige nodules; also note the thickened and folded intestinal wall. b Proximal ileum: blunted villi with large amounts of Eimeria spp. in the epithelium. Arrowheads point at some of the numerous crypt abscesses. There is also infiltration of inflammatory cells in lamina propria and superficial haemorrhage and hyperaemia. c Heavy infection of surface epithelium of the proximal ileum with both gamonts (arrowhead) and zygotes (arrow) present. d Proximal ileum: large area of epithelial necrosis (arrowheads) with atrophy of villi and full destruction of normal architecture. There is marked infiltration of inflammatory cells, proliferation of fibrous tissue, hyperaemia and haemorrhage. e Basis of caecum: The surface epithelium is flattened (*), hyperplastic (arrow) and eroded (arrowhead). There is a colonic gland with hyperplastic epithelium and debris and next to this a destructed area with hyperaemia. f Basis of caecum: arrow points at a marked infiltration of inflammatory cells, mostly monocytes, with some Eimeria-zygotes (arrowhead) in submucosa (SM). A lymph vessel (*) with degenerated Eimeria (MM: muscularis mucosa). b-f Haematoxylin and eosin staining, scale-bars and magnification: b, 100 μm, 100×; c, 25 μm, 400×; and d-f, 50 μm, 200×

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