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Table 2 Maximum likelihood estimates and 95% confidence intervals (CI) for the geometric mean efficacy

From: Controlled efficacy trial confirming toltrazuril resistance in a field isolate of ovine Eimeria spp.

Sample 2 (day)

Eimeria spp.

Slope

Mean efficacy (%)

Lower 95% CI

Higher 95% CI

n a

Interpretation

Treated

Control

14

All species

1.32

-0.3

-1116.8

92.5

10

10

Reduced efficacy

14

E. c/w

0.26

–

–

–

10

10

Invalid

14

E. ovi

1.33

-114.8

-431.4

16.8

10

10

Reduced efficacy

14

Non-pathogenic

1.22

-48.3

-252.3

44.0

10

10

Reduced efficacy

15

All species

1.69

13.5

-90.9

61.2

10

10

Reduced efficacy

15

E. c/w

0

–

–

–

10

10

Invalid

15

E. ovi

1.47

8.7

-102.8

63.2

10

10

Reduced efficacy

15

Non-pathogenic

1.31

33.0

-73.6

70.2

10

10

Reduced efficacy

16

All species

1.37

-93.4

-395.5

29.5

10

10

Reduced efficacy

16

E. c/w

0.26

–

–

–

10

10

Invalid

16

E. ovi

1.33

-114.8

-418.7

9.5

10

10

Reduced efficacy

16

Non-pathogenic

1.22

-48.3

-265.8

37.3

10

10

Reduced efficacy

17

All species

1.40

-41.9

-139.4

16.6

10

10

Reduced efficacy

17

E. c/w

0.73

-202,2

-834.6

-25.6

10

10

Caution: reduced efficacy

17

E. ovi

1.51

-41.2

-260.1

42.8

10

10

Reduced efficacy

17

Non-pathogenic

1.38

-37.0

-241.0

44.0

10

10

Reduced efficacy

18

All species

1.24

-97.2

-684.4

45.6

8

8

Reduced efficacy

18

E. c/w

0.77

-198.2

-769.8

-3.6

8

8

Reduced efficacy

18

E. ovi

1.47

-56.1

-316.6

47.6

8

8

Reduced efficacy

18

Non-pathogenic

1.35

-228.6

-815.1

-15.1

8

8

Reduced efficacy

  1. Notes: The estimates were based on post-treatment oocyst counts for five time intervals between sample 1 (day 7 after infection) and sample 2, and was calculated according to the FOCRT [6]. A slope ≥ 0.5 and < 0.75 was evaluated with caution, whereas a slope < 0.5 was interpreted as invalid
  2. aFour lambs were euthanized at day 17
  3. Abbreviations: E. ovi, E. ovinoidalis; E. c/w, E. crandallis/weybridgensis; Non-pathogenic, all species except E. ovinoidalis and E. crandallis/weybridgensis