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Table 2 Maximum likelihood estimates and 95% confidence intervals (CI) for the geometric mean efficacy

From: Controlled efficacy trial confirming toltrazuril resistance in a field isolate of ovine Eimeria spp.

Sample 2 (day) Eimeria spp. Slope Mean efficacy (%) Lower 95% CI Higher 95% CI n a Interpretation
Treated Control
14 All species 1.32 -0.3 -1116.8 92.5 10 10 Reduced efficacy
14 E. c/w 0.26 10 10 Invalid
14 E. ovi 1.33 -114.8 -431.4 16.8 10 10 Reduced efficacy
14 Non-pathogenic 1.22 -48.3 -252.3 44.0 10 10 Reduced efficacy
15 All species 1.69 13.5 -90.9 61.2 10 10 Reduced efficacy
15 E. c/w 0 10 10 Invalid
15 E. ovi 1.47 8.7 -102.8 63.2 10 10 Reduced efficacy
15 Non-pathogenic 1.31 33.0 -73.6 70.2 10 10 Reduced efficacy
16 All species 1.37 -93.4 -395.5 29.5 10 10 Reduced efficacy
16 E. c/w 0.26 10 10 Invalid
16 E. ovi 1.33 -114.8 -418.7 9.5 10 10 Reduced efficacy
16 Non-pathogenic 1.22 -48.3 -265.8 37.3 10 10 Reduced efficacy
17 All species 1.40 -41.9 -139.4 16.6 10 10 Reduced efficacy
17 E. c/w 0.73 -202,2 -834.6 -25.6 10 10 Caution: reduced efficacy
17 E. ovi 1.51 -41.2 -260.1 42.8 10 10 Reduced efficacy
17 Non-pathogenic 1.38 -37.0 -241.0 44.0 10 10 Reduced efficacy
18 All species 1.24 -97.2 -684.4 45.6 8 8 Reduced efficacy
18 E. c/w 0.77 -198.2 -769.8 -3.6 8 8 Reduced efficacy
18 E. ovi 1.47 -56.1 -316.6 47.6 8 8 Reduced efficacy
18 Non-pathogenic 1.35 -228.6 -815.1 -15.1 8 8 Reduced efficacy
  1. Notes: The estimates were based on post-treatment oocyst counts for five time intervals between sample 1 (day 7 after infection) and sample 2, and was calculated according to the FOCRT [6]. A slope ≥ 0.5 and < 0.75 was evaluated with caution, whereas a slope < 0.5 was interpreted as invalid
  2. aFour lambs were euthanized at day 17
  3. Abbreviations: E. ovi, E. ovinoidalis; E. c/w, E. crandallis/weybridgensis; Non-pathogenic, all species except E. ovinoidalis and E. crandallis/weybridgensis