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Fig. 3 | Parasites & Vectors

Fig. 3

From: PD-1 deficiency promotes TFH cells expansion in ITV-immunized mice by upregulating cytokines secretion

Fig. 3

PD-1 deficiency contributed to the expansion of TFR cells in both naïve and immunized mice. Splenocytes were isolated from immunized WT (n = 5) and PD-1-/- mice (n = 5) at the indicated times after the final immunization, and both the frequency and number of TFR cells were analyzed by FACS. a Representative FACS analysis of CD4+ICOS+CXCR5+Foxp3+CD19 cells. b, c Statistical analysis of the frequency and number of TFR cells from ITV-immunized WT and PD-1-/- mice on days 7, 14 and 21 after the final immunization. Three individual experiments were performed. The data are presented as the mean ± SD. Data were compared with the two-way ANOVA. Abbreviation: n, number of samples

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