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Fig. 5 | Parasites & Vectors

Fig. 5

From: PD-1 deficiency promotes TFH cells expansion in ITV-immunized mice by upregulating cytokines secretion

Fig. 5

Frequency and number of Plasmodium-specific TFH cells in the spleens of ITV-immunized WT and PD-1-/- mice. Splenocytes were isolated from immunized WT (n = 5) and PD-1-/- mice (n = 5) on days 7 and 14 after the final immunization and the Plasmodium-specific TFH cells were analyzed by FACS. a Representative FACS analysis of Foxp3-CD19-CD4+CD11a+CD49d+CXCR5+ICOS+ Plasmodium-specific TFH cells. b, c Statistical analysis of the frequency and number of Plasmodium-specific TFH cells (Foxp3-CD19-CD4+CD11a+CD49d+ CXCR5+ICOS+) from immunized WT and PD-1-/- mice. d Representative FACS analysis of Foxp3-CD19-CD4+CD11a+CD49d+CXCR5+Bcl6+ Plasmodium-specific TFH cells. e, f Statistical analysis of the frequency and number of Plasmodium-specific TFH cells (Foxp3-CD19-CD4+CD11a+CD49d+CXCR5+Bcl6+) from immunized WT and PD-1-/- mice. Three individual experiments were performed. The data are presented as the mean ± SD. Data were compared with two-way ANOVA. Abbreviation: n, number of samples

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