Table 2 Upregulated and downregulated genes with fold change (FC) ≥ 20 at 2 and 24 h post-infection
From: Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi
Gene ID | Description | FC | Gene ID | Description | FC |
|---|---|---|---|---|---|
2 h | |||||
Upregulated 105 trypomastigotes | Downregulated 105 trypomastigotes | ||||
LDOC1 | Leucine zipper, downregulated in cancer 1 | 71.43 | SLC9B1 | Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 65.64 |
ADAM12 | ADAM metallopeptidase domain 12 | 54.99 | LBP | Lipopolysaccharide binding protein | 60.23 |
PNMT | Phenylethanolamine N-methyltransferase | 51.74 | MEDAG | Mesenteric estrogen-dependent adipogenesis | 52.12 |
ADORA3 | Adenosine A3 receptor | 48.44 | SYT1 | Synaptotagmin I | 49.30 |
GH2 | Growth hormone 2 | 44.96 | RGS7BP | Regulator of G-protein signaling 7 binding protein | 49.08 |
PCDHB13 | Protocadherin beta 13 | 44.71 | MT1H | Metallothionein 1H | 47.18 |
CXCL9 | Chemokine (C-X-C motif) ligand 9 | 26.61 | CAPN8 | Calpain 8 | 46.86 |
TLR7 | Toll-like receptor 7 | 23.52 | DCD | Dermcidin | 42.36 |
TLR8 | Toll-like receptor 8 | 21.74 | HTR5A | 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled | 42.25 |
CD46 | CD46 molecule, complement regulatory protein | 21.48 | KALRN | Kalirin, RhoGEF kinase | 42.01 |
C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 21.41 | CDH18 | Cadherin 18, type 2 | 35.52 |
Upregulated 106 trypomastigotes | Downregulated 106 trypomastigotes | ||||
LOC101060810 | Zinc finger protein 98-like | 68.80 | SNRPG | Small nuclear ribonucleoprotein polypeptide G | 73.40 |
LMOD1 | Leiomodin 1 (smooth muscle) | 62.19 | TUBA1C | Tubulin, alpha 1c | 71.97 |
SPIN4 | Spindlin family, member 4 | 53.45 | TSC22D1 | TSC22 domain family, member 1 | 71.15 |
LINC00551 | Long intergenic non-protein coding RNA 551 | 52.98 | CD14 | CD14 molecule | 70.98 |
PSG3 | Pregnancy specific beta-1-glycoprotein 3 | 47.68 | MBNL2 | Muscleblind-like splicing regulator 2 | 64.74 |
PSG8 | Pregnancy specific beta-1-glycoprotein 8 | 45.17 | FUT3 | Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase. Lewis blood group) | 63.73 |
PSPHP1 | Phosphoserine phosphatase pseudogene 1 | 44.87 | GCGR | Glucagon receptor | 62.52 |
PSG1 | Pregnancy specific beta-1-glycoprotein 1 | 42.74 | IL6 | Interleukin 6 (interferon, beta 2) | 62.25 |
PCDHB13 | Protocadherin beta 13 | 41.77 | NOG | Noggin | 60.99 |
HULC | Hepatocellular carcinoma upregulated long non-coding RNA | 40.94 | SBSN | Suprabasin | 60.01 |
ADAMTSL3 | ADAMTS-like 3 | 34.70 | FAM89A | Family with sequence similarity 89, member A | 57.57 |
24 h | |||||
Upregulated 105 trypomatigotes | Downregulated 105 trypomastigotes | ||||
GCGR | Glucagon receptor | 26.78 | GEMIN2 | Gem (nuclear organelle) associated protein 2 | 66.26 |
CHRDL2 | Chordin-like 2 | 26.46 | GUCA1A | Guanylate cyclase activator 1A (retina) | 50.37 |
TAC3 | Tachykinin 3 | 23.82 | LOC340515 | Uncharacterized LOC340515 | 47.71 |
STC1 | Stanniocalcin 1 | 21.80 | LINC00200 | Long intergenic non-protein coding RNA 200 | 42.88 |
SLC43A3 | Solute carrier family 43, member 3 | 21.60 | FAM182B | Family with sequence similarity 182, member B | 41.35 |
PENK | Proenkephalin | 21.06 | SEC14L4 | SEC14-like 4 (S. cerevisiae) | 38.81 |
SLC44A4 | Solute carrier family 44, member 4 | 21.02 | CLEC6A | C-type lectin domain family 6, member A | 38.42 |
HLA-DQB1 | Major histocompatibility complex, class II, DQ beta 1 | 20.99 | SNORA65 | Small nucleolar RNA, H/ACA box 65 | 36.94 |
ANTXR1 | Anthrax toxin receptor 1 | 20.21 | LOC541473 | FK506 binding protein 6, 36kDa pseudogene | 36.81 |
SBSN | Suprabasin | 20.18 | AKR7L | Aldo-keto reductase family 7-like | 36.51 |
Upregulated 106 trypomastigotes | Downregulated 106 trypomastigotes | ||||
MMP10 | Matrix metallopeptidase 10 (stromelysin 2) | 105.67 | DNMT3L | DNA (cytosine-5-)-methyltransferase 3-like | 63.39 |
CSH2 | Chorionic somatomammotropin hormone 2 | 68.94 | KLRG2 | Killer cell lectin-like receptor subfamily G, member 2 | 46.45 |
GH2 | Growth hormone 2 | 68.66 | MS4A6A | Membrane-spanning 4-domains. subfamily A, member 6A | 40.49 |
CCL20 | Chemokine (C-C motif) ligand 20 | 58.87 | TMEM45B | Transmembrane protein 45B | 40.27 |
ENO2 | Enolase 2 (gamma, neuronal) | 53.70 | IGFBP1 | Insulin-like growth factor binding protein 1 | 39.99 |
SOD2 | Superoxide dismutase 2, mitochondrial | 53.42 | PSPHP1 | Phosphoserine phosphatase pseudogene 1 | 39.83 |
PCDHB13 | Protocadherin beta 13 | 53.33 | TPTE2P3 | Transmembrane phosphoinositide 3-phosphatase and Tensin homolog 2 pseudogene 3 | 39.87 |
SELE | Selectin E | 52.93 | MNDA | myeloid cell nuclear differentiation antigen | 38.99 |
ABO | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 51.78 | FGF14-AS2 | FGF14 antisense RNA 2 | 38.98 |
STC1 | Stanniocalcin 1 | 51.40 | PTX3 | Pentraxin 3, long | 38.59 |