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Table 2 Upregulated and downregulated genes with fold change (FC) ≥ 20 at 2 and 24 h post-infection

From: Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi

Gene ID Description FC Gene ID Description FC
2 h
 Upregulated 105 trypomastigotes  Downregulated 105 trypomastigotes
  LDOC1 Leucine zipper, downregulated in cancer 1 71.43   SLC9B1 Solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 65.64
  ADAM12 ADAM metallopeptidase domain 12 54.99   LBP Lipopolysaccharide binding protein 60.23
  PNMT Phenylethanolamine N-methyltransferase 51.74   MEDAG Mesenteric estrogen-dependent adipogenesis 52.12
  ADORA3 Adenosine A3 receptor 48.44   SYT1 Synaptotagmin I 49.30
  GH2 Growth hormone 2 44.96   RGS7BP Regulator of G-protein signaling 7 binding protein 49.08
  PCDHB13 Protocadherin beta 13 44.71   MT1H Metallothionein 1H 47.18
  CXCL9 Chemokine (C-X-C motif) ligand 9 26.61   CAPN8 Calpain 8 46.86
  TLR7 Toll-like receptor 7 23.52   DCD Dermcidin 42.36
  TLR8 Toll-like receptor 8 21.74   HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 42.25
  CD46 CD46 molecule, complement regulatory protein 21.48   KALRN Kalirin, RhoGEF kinase 42.01
  C1QTNF3 C1q and tumor necrosis factor related protein 3 21.41   CDH18 Cadherin 18, type 2 35.52
 Upregulated 106 trypomastigotes  Downregulated 106 trypomastigotes
  LOC101060810 Zinc finger protein 98-like 68.80   SNRPG Small nuclear ribonucleoprotein polypeptide G 73.40
  LMOD1 Leiomodin 1 (smooth muscle) 62.19   TUBA1C Tubulin, alpha 1c 71.97
  SPIN4 Spindlin family, member 4 53.45   TSC22D1 TSC22 domain family, member 1 71.15
  LINC00551 Long intergenic non-protein coding RNA 551 52.98   CD14 CD14 molecule 70.98
  PSG3 Pregnancy specific beta-1-glycoprotein 3 47.68   MBNL2 Muscleblind-like splicing regulator 2 64.74
  PSG8 Pregnancy specific beta-1-glycoprotein 8 45.17   FUT3 Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase. Lewis blood group) 63.73
  PSPHP1 Phosphoserine phosphatase pseudogene 1 44.87   GCGR Glucagon receptor 62.52
  PSG1 Pregnancy specific beta-1-glycoprotein 1 42.74   IL6 Interleukin 6 (interferon, beta 2) 62.25
  PCDHB13 Protocadherin beta 13 41.77   NOG Noggin 60.99
  HULC Hepatocellular carcinoma upregulated long non-coding RNA 40.94   SBSN Suprabasin 60.01
  ADAMTSL3 ADAMTS-like 3 34.70   FAM89A Family with sequence similarity 89, member A 57.57
24 h
 Upregulated 105 trypomatigotes  Downregulated 105 trypomastigotes
  GCGR Glucagon receptor 26.78   GEMIN2 Gem (nuclear organelle) associated protein 2 66.26
  CHRDL2 Chordin-like 2 26.46   GUCA1A Guanylate cyclase activator 1A (retina) 50.37
  TAC3 Tachykinin 3 23.82   LOC340515 Uncharacterized LOC340515 47.71
  STC1 Stanniocalcin 1 21.80   LINC00200 Long intergenic non-protein coding RNA 200 42.88
  SLC43A3 Solute carrier family 43, member 3 21.60   FAM182B Family with sequence similarity 182, member B 41.35
  PENK Proenkephalin 21.06   SEC14L4 SEC14-like 4 (S. cerevisiae) 38.81
  SLC44A4 Solute carrier family 44, member 4 21.02   CLEC6A C-type lectin domain family 6, member A 38.42
  HLA-DQB1 Major histocompatibility complex, class II, DQ beta 1 20.99   SNORA65 Small nucleolar RNA, H/ACA box 65 36.94
  ANTXR1 Anthrax toxin receptor 1 20.21   LOC541473 FK506 binding protein 6, 36kDa pseudogene 36.81
  SBSN Suprabasin 20.18   AKR7L Aldo-keto reductase family 7-like 36.51
 Upregulated 106 trypomastigotes  Downregulated 106 trypomastigotes
  MMP10 Matrix metallopeptidase 10 (stromelysin 2) 105.67   DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 63.39
  CSH2 Chorionic somatomammotropin hormone 2 68.94   KLRG2 Killer cell lectin-like receptor subfamily G, member 2 46.45
  GH2 Growth hormone 2 68.66   MS4A6A Membrane-spanning 4-domains. subfamily A, member 6A 40.49
  CCL20 Chemokine (C-C motif) ligand 20 58.87   TMEM45B Transmembrane protein 45B 40.27
  ENO2 Enolase 2 (gamma, neuronal) 53.70   IGFBP1 Insulin-like growth factor binding protein 1 39.99
  SOD2 Superoxide dismutase 2, mitochondrial 53.42   PSPHP1 Phosphoserine phosphatase pseudogene 1 39.83
  PCDHB13 Protocadherin beta 13 53.33   TPTE2P3 Transmembrane phosphoinositide 3-phosphatase and Tensin homolog 2 pseudogene 3 39.87
  SELE Selectin E 52.93   MNDA myeloid cell nuclear differentiation antigen 38.99
  ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 51.78   FGF14-AS2 FGF14 antisense RNA 2 38.98
  STC1 Stanniocalcin 1 51.40   PTX3 Pentraxin 3, long 38.59