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Table 2 Flea counts on naturally infested dogs in households in Florida before and after treatment with a single oral dose of fluralaner or three consecutive monthly doses of sarolaner

From: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

Treatment group No. of dogs on day 0   Days post-treatment
0 7 14 21 28–30 40–45 56–60 82–86
Fluralaner1 18 Geomean flea count3 26.9b,x 0.1a,y 0.3a,y 0.1a,y 0.0a,y 0.1a,y 0.0a,y 0.0a,y
Range (5–131) (0–1) (0–3) (0–2) (0–0) (0–2) (0–0) (0–0)
% control4   99.7 99.0 99.8 100 99.6 100 100
% (#) dogs with no fleas 0.0a,x
(0/18)
88.9a,y
(16/18)
72.2a,y
(13/18)
94.4a,y
(17/18)
100a,y
(18/18)
88.9a,y
(16/18)
100a,y
(18/18)
100a,y
(18/18)
Sarolaner2 13 Geomean flea count3 37.9a,x 0.1a,y 0.1a,y 0.2a,y 0.1a,y 0.0a,y 0.0a,y 0.0a,y
Range (10–171) (0–1) (0–1) (0–2) (0–1) (0–0) (0–0) (0–0)
% control4   99.7 99.8 99.4 99.9 100 100 100
% (#) dogs with no fleas 0.0a,x
(0/13)
84.6a,y
(11/13)
91.7a,y
(11/12)
76.9a,y
(10/13)
92.3a,y
(12/13)
100a,y
(13/13)
100a,y
(13/13)
100a,y
(12/12)
  1. 1In the fluralaner group dogs were treated once orally on day 0 (Bravecto chew; Merck Animal Health, Madison, NJ, USA)
  2. 2In the sarolaner group dogs were treated on day 0 and once between days 28–30 and 56–60 (Simparica chew; Zoetis, Whippany, NJ, USA)
  3. 3Geometric mean numbers of fleas in area counts
  4. 4{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts) / day 0 geometric mean animal area flea counts)} × 100
  5. a,bGeometric mean flea counts in a column with unlike letter superscripts are significantly different (day 0, P = 0.034; │t│ = 2.14 )
  6. x,yGeometric mean flea counts in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; │t│ ≥ 22.83)
  7. a,bPercent of flea- free dogs in a column with like letter superscripts are not significantly different (P > 0.284; Fisher’s exact test)
  8. x,yPercent of flea- free dogs in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; Fisher’s exact test)