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Table 2 Flea counts on naturally infested dogs in households in Florida before and after treatment with a single oral dose of fluralaner or three consecutive monthly doses of sarolaner

From: In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA

Treatment group

No. of dogs on day 0

 

Days post-treatment

0

7

14

21

28–30

40–45

56–60

82–86

Fluralaner1

18

Geomean flea count3

26.9b,x

0.1a,y

0.3a,y

0.1a,y

0.0a,y

0.1a,y

0.0a,y

0.0a,y

Range

(5–131)

(0–1)

(0–3)

(0–2)

(0–0)

(0–2)

(0–0)

(0–0)

% control4

 

99.7

99.0

99.8

100

99.6

100

100

% (#) dogs with no fleas

0.0a,x

(0/18)

88.9a,y

(16/18)

72.2a,y

(13/18)

94.4a,y

(17/18)

100a,y

(18/18)

88.9a,y

(16/18)

100a,y

(18/18)

100a,y

(18/18)

Sarolaner2

13

Geomean flea count3

37.9a,x

0.1a,y

0.1a,y

0.2a,y

0.1a,y

0.0a,y

0.0a,y

0.0a,y

Range

(10–171)

(0–1)

(0–1)

(0–2)

(0–1)

(0–0)

(0–0)

(0–0)

% control4

 

99.7

99.8

99.4

99.9

100

100

100

% (#) dogs with no fleas

0.0a,x

(0/13)

84.6a,y

(11/13)

91.7a,y

(11/12)

76.9a,y

(10/13)

92.3a,y

(12/13)

100a,y

(13/13)

100a,y

(13/13)

100a,y

(12/12)

  1. 1In the fluralaner group dogs were treated once orally on day 0 (Bravecto chew; Merck Animal Health, Madison, NJ, USA)
  2. 2In the sarolaner group dogs were treated on day 0 and once between days 28–30 and 56–60 (Simparica chew; Zoetis, Whippany, NJ, USA)
  3. 3Geometric mean numbers of fleas in area counts
  4. 4{(Day 0 geometric mean animal area flea counts – day x geometric mean animal area flea counts) / day 0 geometric mean animal area flea counts)} × 100
  5. a,bGeometric mean flea counts in a column with unlike letter superscripts are significantly different (day 0, P = 0.034; │t│ = 2.14 )
  6. x,yGeometric mean flea counts in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; │t│ ≥ 22.83)
  7. a,bPercent of flea- free dogs in a column with like letter superscripts are not significantly different (P > 0.284; Fisher’s exact test)
  8. x,yPercent of flea- free dogs in a row with unlike letter superscripts are significantly different from day 0 (P < 0.001; Fisher’s exact test)