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Table 3 Enteromyxum leei exposure induces the most significant changes in intestine

From: Hints on T cell responses in a fish-parasite model: Enteromyxum leei induces differential expression of T cell signature molecules depending on the organ and the infection status

Cell types

Gene

Head kidney

Spleen

Anterior intestine

Posterior intestine

T cells

 Pan T cell

zap70

0.63 ± 0.04*

0.82 ± 0.07

1.57 ± 0.15*

1.23 ± 0.13

cd3ζ

0.62 ± 0.06*

1.09 ± 0.06

1.63 ± 0.16*

0.97 ± 0.09

 TH cells

cd4-1

0.50 ± 0.04*

0.91 ± 0.13

1.44 ± 0.16*

1.07 ± 0.11

cd4-2

0.70 ± 0.11*

1.25 ± 0.18

1.59 ± 0.10*

1.22 ± 0.12

 CTLs

cd8α

0.53 ± 0.06*

0.84 ± 0.10

1.92 ± 0.34*

0.89 ± 0.14

cd8β

0.47 ± 0.07*

0.80 ± 0.16

1.69 ± 0.26*

0.79 ± 0.09

 Transcription factors

tbet

1.03 ± 0.12

0.94 ± 0.09

2.17 ± 0.27*

1.67 ± 0.21*

gata3

0.72 ± 0.07

0.82 ± 0.09

0.74 ± 0.11

1.22 ± 0.13

foxp3

0.59 ± 0.06*

1.02 ± 0.14

0.99 ± 0.13

1.23 ± 0.20

 Driver/effector cytokines

tnfα

1.04 ± 0.21

1.86 ± 0.430.08

1.34 ± 0.130.09

4.38 ± 2.96

ifnγ

0.93 ± 0.08

1.05 ± 0.04

3.57 ± 0.45*

6.22 ± 1.15*

il12(p40)

0.49 ± 0.06

1.53 ± 0.40

0.70 ± 0.12

0.62 ± 0.160.07

il4/13a

0.93 ± 0.19

1.89 ± 0.430.08

1.07 ± 0.16

3.22 ± 0.97*

Il4/13b

0.91 ± 0.07

0.72 ± 0.090.06

0.91 ± 0.08

1.00 ± 0.09

il6

2.09 ± 0.83

0.81 ± 0.13

1.95 ± 0.70

10.34 ± 3.75*

il10

0.92 ± 0.09

1.34 ± 0.13*

2.04 ± 0.28*

1.56 ± 0.25*

tgfβ

1.05 ± 0.15

1.27 ± 0.18

0.77 ± 0.09

0.54 ± 0.04*

il17a/f

2.15 ± 1.27

2.08 ± 0.60

7.09 ± 2.75*

7.28 ± 1.63*

 Cytotoxic enzymes

gzma

0.91 ± 0.19

1.73 ± 0.260.06

9.32 ± 1.69*

10.97 ± 2.40*

gzmb

1.13 ± 0.20

1.22 ± 0.15

1.10 ± 0.22

0.50 ± 0.07*

prf1

0.89 ± 0.12

1.02 ± 0.07

2.08 ± 0.60*

0.54 ± 0.07*

B cells

 B cells

mIgM

0.81 ± 0.12

1.05 ± 0.16

2.92 ± 0.75*

3.55 ± 0.57*

mIgT

0.68 ± 0.090.06

0.58 ± 0.12*

1.65 ± 0.37

1.75 ± 0.47

IgD

0.97 ± 0.12

0.90 ± 0.18

1.86 ± 0.36*

1.92 ± 0.500.09

pax5

0.93 ± 0.10

0.92 ± 0.13

1.59 ± 0.22*

2.49 ± 0.35*

 Plasma cells

sIgM

1.05 ± 0.16

1.23 ± 0.15

13.54 ± 5.30*

7.46 ± 1.46*

sIgT

0.44 ± 0.23

1.00 ± 0.22

10.35 ± 7.80.09

104.29 ± 890.09

NCC cells

 NCC

nccrp1

1.09 ± 0.11

1.93 ± 0.28*

0.87 ± 0.16

0.99 ± 0.11

Myeloid cells

 Eosinophils

epx

1.09 ± 0.08

3.62 ± 0.63*

2.44 ± 1.02

1.18 ± 0.31

 Macrophages

mpeg1

1.15 ± 0.18

1.45 ± 0.270.09

0.83 ± 0.11

0.92 ± 0.11

  1. Mean ± SEM of the fold changes of the 30 studied genes in RCPT fish (n = 10) calculated relative to the CTRL group (n = 10) in each tissue. Bold values indicate significant up- (values > 1) or downregulation (values < 1). Asterisks (*) indicate significant differences at P < 0.05. Superscript numbers indicate the P-values between 0.05 and 0.1
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Parasites & Vectors

ISSN: 1756-3305

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