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Table 3 Enteromyxum leei exposure induces the most significant changes in intestine

From: Hints on T cell responses in a fish-parasite model: Enteromyxum leei induces differential expression of T cell signature molecules depending on the organ and the infection status

Cell types Gene Head kidney Spleen Anterior intestine Posterior intestine
T cells
Pan T cell zap70 0.63 ± 0.04* 0.82 ± 0.07 1.57 ± 0.15* 1.23 ± 0.13
cd3ζ 0.62 ± 0.06* 1.09 ± 0.06 1.63 ± 0.16* 0.97 ± 0.09
 TH cells cd4-1 0.50 ± 0.04* 0.91 ± 0.13 1.44 ± 0.16* 1.07 ± 0.11
cd4-2 0.70 ± 0.11* 1.25 ± 0.18 1.59 ± 0.10* 1.22 ± 0.12
 CTLs cd8α 0.53 ± 0.06* 0.84 ± 0.10 1.92 ± 0.34* 0.89 ± 0.14
cd8β 0.47 ± 0.07* 0.80 ± 0.16 1.69 ± 0.26* 0.79 ± 0.09
 Transcription factors tbet 1.03 ± 0.12 0.94 ± 0.09 2.17 ± 0.27* 1.67 ± 0.21*
gata3 0.72 ± 0.07 0.82 ± 0.09 0.74 ± 0.11 1.22 ± 0.13
foxp3 0.59 ± 0.06* 1.02 ± 0.14 0.99 ± 0.13 1.23 ± 0.20
 Driver/effector cytokines tnfα 1.04 ± 0.21 1.86 ± 0.430.08 1.34 ± 0.130.09 4.38 ± 2.96
ifnγ 0.93 ± 0.08 1.05 ± 0.04 3.57 ± 0.45* 6.22 ± 1.15*
il12(p40) 0.49 ± 0.06 1.53 ± 0.40 0.70 ± 0.12 0.62 ± 0.160.07
il4/13a 0.93 ± 0.19 1.89 ± 0.430.08 1.07 ± 0.16 3.22 ± 0.97*
Il4/13b 0.91 ± 0.07 0.72 ± 0.090.06 0.91 ± 0.08 1.00 ± 0.09
il6 2.09 ± 0.83 0.81 ± 0.13 1.95 ± 0.70 10.34 ± 3.75*
il10 0.92 ± 0.09 1.34 ± 0.13* 2.04 ± 0.28* 1.56 ± 0.25*
tgfβ 1.05 ± 0.15 1.27 ± 0.18 0.77 ± 0.09 0.54 ± 0.04*
il17a/f 2.15 ± 1.27 2.08 ± 0.60 7.09 ± 2.75* 7.28 ± 1.63*
 Cytotoxic enzymes gzma 0.91 ± 0.19 1.73 ± 0.260.06 9.32 ± 1.69* 10.97 ± 2.40*
gzmb 1.13 ± 0.20 1.22 ± 0.15 1.10 ± 0.22 0.50 ± 0.07*
prf1 0.89 ± 0.12 1.02 ± 0.07 2.08 ± 0.60* 0.54 ± 0.07*
B cells
 B cells mIgM 0.81 ± 0.12 1.05 ± 0.16 2.92 ± 0.75* 3.55 ± 0.57*
mIgT 0.68 ± 0.090.06 0.58 ± 0.12* 1.65 ± 0.37 1.75 ± 0.47
IgD 0.97 ± 0.12 0.90 ± 0.18 1.86 ± 0.36* 1.92 ± 0.500.09
pax5 0.93 ± 0.10 0.92 ± 0.13 1.59 ± 0.22* 2.49 ± 0.35*
 Plasma cells sIgM 1.05 ± 0.16 1.23 ± 0.15 13.54 ± 5.30* 7.46 ± 1.46*
sIgT 0.44 ± 0.23 1.00 ± 0.22 10.35 ± 7.80.09 104.29 ± 890.09
NCC cells
 NCC nccrp1 1.09 ± 0.11 1.93 ± 0.28* 0.87 ± 0.16 0.99 ± 0.11
Myeloid cells
 Eosinophils epx 1.09 ± 0.08 3.62 ± 0.63* 2.44 ± 1.02 1.18 ± 0.31
 Macrophages mpeg1 1.15 ± 0.18 1.45 ± 0.270.09 0.83 ± 0.11 0.92 ± 0.11
  1. Mean ± SEM of the fold changes of the 30 studied genes in RCPT fish (n = 10) calculated relative to the CTRL group (n = 10) in each tissue. Bold values indicate significant up- (values > 1) or downregulation (values < 1). Asterisks (*) indicate significant differences at P < 0.05. Superscript numbers indicate the P-values between 0.05 and 0.1