Fig. 6

The potential impact of insecticide resistance on combined-insecticide control interventions. The legend in each panel shows the percentage of decreased survival imposed by the intervention on each parameter for each of the three genotypes. The blue line shows the resistant allele frequency over time and the black line shows the total number of female adult mosquitoes. As in Fig. 5, the magnitude of the resistance phenotype was not sufficient to prevent a population crash although the smaller, resistant, populations may be sufficiently large to allow malaria transmission (see Table 6 and main text for details). Resistance was assumed to be dominant, interventions started with a resistance allele frequency of 50% and the three genotypes in Hardy-Weinberg equilibrium. Abbreviations: IRS, indoor residual spraying; ITN, insecticide-treated net; SS, the homozygous sensitive genotype; SR, the heterozygous sensitive/resistant genotype; RR, the homozygous resistant genotype