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Table 1 Study 1 counts in untreated control and lotilaner-treated dogs when live ticks were removed 48 h post-treatment and 72 h following each post-treatment infestation

From: Laboratory evaluations of the 3-month efficacy of oral lotilaner (Credelio™) against experimental infestations of dogs with the Australian paralysis tick, Ixodes holocyclus

Day of study

Arithmetic mean ± SD

Geometric mean

t-value

P-value

Efficacy (%)a

Control

Lotilaner

Control

Lotilaner

2

11.4 ± 1.1

0.0 ± 0.0

11.3

0

t(14) = 77.2

<0.0001

100

31

11.6 ± 0.7

0.1 ± 0.4

11.6

0.1

t(14) = 27.4

<0.0001

99.2

59

11.5 ± 1.1

0.0 ± 0.0

11.5

0

t(14) = 76.7

<0.0001

100

73

10.8 ± 1.3

0.0 ± 0.0

10.7

0

t(14) = 62.1

<0.0001

100

80

10.5 ± 0.9

0.0 ± 0.0

10.5

0

t(14) = 85.2

<0.0001

100

87

10.9 ± 1.0

0.0 ± 0.0

10.8

0

t(14) = 81.0

<0.0001

100

94

11.0 ± 0.9

0.4 ± 0.5

11.0

0.3

t(14) = 17.1

<0.0001

97.3

  1. aEfficacy based on geometric means
  2. Abbreviation: SD, standard deviation