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Table 2 Demodex canis mite count reduction in dogs treated three times at a monthly interval with oral afoxolaner

From: Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe

 

Day 0

Day 28

Day 56

Day 84

Total number of dogs (n)

50

50

49

48

Mean mite count (n)

183

22.8

6.4

3.5

Count range (n)

13–2349

0–191

0–65

0–53

Reduction (%)

na

87.6

96.5

98.1

Mite-free dogs (%)a (no. of mite-free dogs/total no. of dogs)

na

12 (6/50)

38.8 (19/49)

62.5 (30/48)

Signed rank (S)

na

-599

-612

-588

Degrees of freedom

na

48

48

47

P-value

na

<0.0001

<0.0001

<0.0001

NexGard-treated animals

 Number of dogs (n)

31

31

30

29

 Mean mite count (n)

229.8

26.5

7.4

4.1

 Count range (n)

18–2349

0–191

0–65

0–53

 Reduction (%)

na

88.5

96.8

98.2

 Signed rank (S)

na

-224

-232.5

-217.5

 Degrees of freedom

 

29

29

28

P-value

na

<0.0001

<0.0001

<0.0001

NexGard Spectra-treated animals

 Number of dogs (n)

19

19

19

19

 Mean mite count (n)

106.6

16.8

4.8

2.7

 Count range (n)

13–386

0–91

0–26

0–37

 Reduction (%)

na

84.3

95.5

97.5

 Signed rank (S)

na

-95

-95

-95

 Degrees of freedom

na

18

18

18

P-value

na

<0.0001

<0.0001

<0.0001

  1. Abbreviation: na not applicable
  2. a Mite-free dogs: absence of mite (live or dead) at count