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Table 11 In vitro effects of glycosides and aglycones on the growth of Leishmania amazonensis in culture. Parasites were counted with a hemocytometer at 24, 48 and 72 h after adding compounds to a culture with an initial concentration of 1 × 106 parasites/ml. Results shown are the mean and SEM of 3 biological replicates. Controls received only PBS

From: Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones

Time of exposure (h)

Control (× 106)

Amygdalin (× 106)

Esculin (× 106)

Mandelonitrile (× 106)

24

6 ± 1

8 ± 2

9 ± 2

1.1 ± 0.5*

48

26 ± 3

32 ± 4

30 ± 6

0.2 ± 0.1**

72

58 ± 5

74 ± 9

62 ± 3

0.6 ± 0***

  1. *P < 0.05, **P < 0.001, ***P < 0.0001. Ordinary one-way ANOVA; Unpaired t-test for post-hoc multiple comparisons
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Parasites & Vectors

ISSN: 1756-3305

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