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Table 11 In vitro effects of glycosides and aglycones on the growth of Leishmania amazonensis in culture. Parasites were counted with a hemocytometer at 24, 48 and 72 h after adding compounds to a culture with an initial concentration of 1 × 106 parasites/ml. Results shown are the mean and SEM of 3 biological replicates. Controls received only PBS

From: Transmission blocking sugar baits for the control of Leishmania development inside sand flies using environmentally friendly beta-glycosides and their aglycones

Time of exposure (h) Control (× 106) Amygdalin (× 106) Esculin (× 106) Mandelonitrile (× 106)
24 6 ± 1 8 ± 2 9 ± 2 1.1 ± 0.5*
48 26 ± 3 32 ± 4 30 ± 6 0.2 ± 0.1**
72 58 ± 5 74 ± 9 62 ± 3 0.6 ± 0***
  1. *P < 0.05, **P < 0.001, ***P < 0.0001. Ordinary one-way ANOVA; Unpaired t-test for post-hoc multiple comparisons