Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

Table 1 Comparative activity and effect of the OXA derivatives against S. mansoni

Compound	S. mansoni adult 72 h IC₅₀ (μM)	Onset of action 100 μM (h)	Most affected sex	Tegumental damage
Compound	S. mansoni adult 72 h IC₅₀ (μM)	Onset of action 100 μM (h)	Most affected sex	Blebbing	Sloughing off	Specific damage pattern/organ
Fc-OXA	11.4^a	4	Males	+	++	Gynaecophoric canal
Rc-OXA	8.7 ^a	24	Males	++	+	Loss of spines
Bn-OXA	11.1 ^a	72	Females	+	+++	Suckers
OXA	> 100	120	Both	β	β	β

ISSN: 1756-3305