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Table 2 Comparative activity and effect of the derivatives against S. haematobium

From: Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

Compound S. haematobium adult 72 h IC50 (μM) Onset of action 100 μM (h) Most affected sex Tegumental damage
Blebbing Sloughing off Specific damage pattern/organ
Fc-OXA 68.1 48 Males + ++ Gynaecophoric canal
Rc-OXA 24.5 24 Males ++ ++ Loss of spines
Bn-OXA 38.6 48 Males + +++ Body creases
OXA > 100 120 Both + β VS invagination
  1. Abbreviations: VS, ventral sucker; β, no difference was observed to control group