Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy

Table 2 Comparative activity and effect of the derivatives against S. haematobium

Compound	S. haematobium adult 72 h IC₅₀ (μM)	Onset of action 100 μM (h)	Most affected sex	Tegumental damage
Compound	S. haematobium adult 72 h IC₅₀ (μM)	Onset of action 100 μM (h)	Most affected sex	Blebbing	Sloughing off	Specific damage pattern/organ
Fc-OXA	68.1	48	Males	+	++	Gynaecophoric canal
Rc-OXA	24.5	24	Males	++	++	Loss of spines
Bn-OXA	38.6	48	Males	+	+++	Body creases
OXA	> 100	120	Both	+	β	VS invagination

Abbreviations: VS, ventral sucker; β, no difference was observed to control group

ISSN: 1756-3305