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Table 1 Geometric (arithmetic) mean counts of live ticks and percent reduction from baseline in each group

From: Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats

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Mean

Reduction (%)

t-statistic (tdf)

P-value

(Pr > t)

Mean

Reduction (%)

t-statistic (tdf)

P-value

(Pr > t)

Per protocol population

 

Fluralaner + moxidectin (n = 152)

Fipronil (n = 77)

1

2.59 (3.67)

  

2.17 (2.61)

  

2

0.05 (0.09)

98.3 (97.7)

t(200.37) = 26.6

<0.0001

0.12 (0.21)

94.4 (92.0)

t(152) = 17.9

<0.0001

3

0.07 (0.16)

97.2 (95.7)

t(228.96) = 24.9

<0.0001

0.11 (0.23)

94.9 (91.0)

t(152) = 17.6

<0.0001

4

0.07 (0.15)

97.3 (95.9)

t(228.17) = 25.0

<0.0001

0.16 (0.23)

92.7 (91.0)

t(144.27) = 17.5

<0.0001

5

0.05 (0.09)

97.9 (97.5)

t(199.31) = 26.5

<0.0001

0.07 (0.10)

97.0 (96.0)

t(119.53) = 21.0

<0.0001

Intent to treat population

 

Fluralaner + moxidectin (n = 171)

Fipronil (n = 86)

1

2.54 (3.61)

  

2.22 (2.70)

  

2

0.04 (0.08)

98.4 (97.9)

t(219.73) = 28.1

<0.0001

0.17 (0.34)

92.2 (87.6)

t(170) = 16.0

<0.0001

3

0.08 (0.15)

96.9 (95.6)

t(255.62) = 25.9

<0.0001

0.15 (0.35)

93.2 (87.0)

t(169) = 16.1

<0.0001

4

0.07 (0.14)

97.3 (96.0)

t(252.87) = 26.2

<0.0001

0.15 (0.22)

93.4 (92.0)

t(156.24) = 18.6

<0.0001

5

0.06 (0.10)

97.6 (97.1)

t(230.92) = 27.2

<0.0001

0.07 (0.11)

96.9 (96.0)

t(132.43) = 21.6

<0.0001