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Table 3 Percent of cats infested with ticks on Day 0 that were free of ticks at subsequent visits

From: Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats

Treatment group

Cats free of ticks (%)

Visit 2

Visit 3

Visit 4

Visit 5

Per protocol population

 Fluralaner + moxidectin

96.1

92.8

93.4

94.1

 Fipronil

88.3

89.6

81.8

92.2

 Lower 97.5% one-sided confidence limita

0.0008

-0.0456

0.0294

-0.0534

P-value for non-inferiorityb

<0.0001

<0.0001

<0.0001

<0.0001

 Intent to treat population

 Fluralaner + moxidectin

96.5

91.8

93.4

93.3

 Fipronil

86.1

88.2

83.1

91.6

 Lower 97.5% one-sided confidence limita

0.0293

-0.0403

0.0215

-0.0530

P-value for non-inferiorityb

<0.0001

<0.0001

<0.0001

<0.0001

  1. aLower 97.5% one-sided confidence limit was well above the non-inferiority limit of -0.15. If the lower confidence limit was above 0, superiority was concluded
  2. bFarrington-Manning method