Table 3 Total differentially expressed KEGG pathways overrepresented/enriched by the differentially expressed genes in cat intestine in response to infection with T. gondii
KEGG pathway | Gene number | FDR corrected P-value | |||||
|---|---|---|---|---|---|---|---|
Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | Cluster 5 | Cluster 6 | ||
Protein digestion and absorption | 1 | 16 | 1 | 10 | 7 | 1 | 2.66E-15 |
Lysosome | 3 | 9 | 1 | 13 | 0 | 1 | 4.44E-06 |
Mineral absorption | 0 | 10 | 1 | 3 | 0 | 0 | 5.75E-05 |
ECM-receptor interaction | 0 | 13 | 1 | 5 | 0 | 0 | 0.000222 |
Pancreatic secretion | 4 | 6 | 0 | 0 | 9 | 0 | 0.000232 |
Galactose metabolism | 2 | 2 | 1 | 6 | 0 | 0 | 0.000677 |
Other glycan degradation | 0 | 3 | 0 | 5 | 0 | 0 | 0.001051 |
Amino sugar and nucleotide sugar metabolism | 2 | 4 | 1 | 6 | 0 | 0 | 0.001526 |
Arginine biosynthesis | 1 | 2 | 1 | 4 | 0 | 0 | 0.002527 |
Bile secretion | 1 | 8 | 2 | 3 | 0 | 0 | 0.00304 |
Alanine, aspartate and glutamate metabolism | 1 | 4 | 2 | 3 | 0 | 0 | 0.003204 |
Retinol metabolism | 2 | 4 | 0 | 4 | 0 | 0 | 0.005355 |
Focal adhesion | 4 | 14 | 1 | 7 | 0 | 0 | 0.010981 |
Starch and sucrose metabolism | 0 | 2 | 1 | 5 | 1 | 0 | 0.011597 |
Sphingolipid metabolism | 0 | 4 | 1 | 5 | 0 | 0 | 0.013042 |
Cell cycle | 17 | 0 | 1 | 0 | 0 | 0 | 0.014158 |
Carbohydrate digestion and absorption | 0 | 2 | 1 | 5 | 1 | 0 | 0.014633 |
Proximal tubule bicarbonate reclamation | 1 | 5 | 1 | 0 | 0 | 0 | 0.014947 |
Arginine and proline metabolism | 1 | 5 | 0 | 4 | 0 | 0 | 0.01764 |
Glycosaminoglycan degradation | 1 | 1 | 0 | 4 | 0 | 0 | 0.01764 |
ABC transporters | 2 | 5 | 0 | 2 | 0 | 0 | 0.021963 |
Glycosphingolipid biosynthesis - globo series | 0 | 1 | 0 | 4 | 0 | 0 | 0.023611 |
Steroid hormone biosynthesis | 1 | 2 | 1 | 3 | 0 | 1 | 0.024807 |
Fructose and mannose metabolism | 1 | 4 | 1 | 2 | 0 | 0 | 0.024807 |
Glycolysis / Gluconeogenesis | 2 | 5 | 1 | 3 | 0 | 0 | 0.024807 |
Chemical carcinogenesis | 1 | 6 | 0 | 2 | 0 | 0 | 0.024807 |
Glutathione metabolism | 3 | 5 | 1 | 0 | 0 | 0 | 0.024807 |
Steroid biosynthesis | 6 | 0 | 0 | 0 | 0 | 0 | 0.025842 |
Drug metabolism - cytochrome P450 | 1 | 6 | 0 | 1 | 0 | 0 | 0.025842 |
Complement and coagulation cascades | 6 | 2 | 3 | 1 | 0 | 0 | 0.026353 |
p53 signaling pathway | 6 | 2 | 3 | 0 | 0 | 0 | 0.026976 |
Glycine, serine and threonine metabolism | 4 | 1 | 2 | 1 | 0 | 0 | 0.027354 |
Renin-angiotensin system | 1 | 3 | 0 | 2 | 0 | 0 | 0.027354 |
Pyrimidine metabolism | 10 | 1 | 2 | 0 | 0 | 0 | 0.03345 |
Amoebiasis | 3 | 7 | 0 | 4 | 0 | 0 | 0.034505 |
Nitrogen metabolism | 3 | 0 | 1 | 1 | 0 | 0 | 0.034505 |