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Table 3 Total differentially expressed KEGG pathways overrepresented/enriched by the differentially expressed genes in cat intestine in response to infection with T. gondii

From: Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii

KEGG pathway Gene number FDR corrected P-value
Cluster 1 Cluster 2 Cluster 3 Cluster 4 Cluster 5 Cluster 6
Protein digestion and absorption 1 16 1 10 7 1 2.66E-15
Lysosome 3 9 1 13 0 1 4.44E-06
Mineral absorption 0 10 1 3 0 0 5.75E-05
ECM-receptor interaction 0 13 1 5 0 0 0.000222
Pancreatic secretion 4 6 0 0 9 0 0.000232
Galactose metabolism 2 2 1 6 0 0 0.000677
Other glycan degradation 0 3 0 5 0 0 0.001051
Amino sugar and nucleotide sugar metabolism 2 4 1 6 0 0 0.001526
Arginine biosynthesis 1 2 1 4 0 0 0.002527
Bile secretion 1 8 2 3 0 0 0.00304
Alanine, aspartate and glutamate metabolism 1 4 2 3 0 0 0.003204
Retinol metabolism 2 4 0 4 0 0 0.005355
Focal adhesion 4 14 1 7 0 0 0.010981
Starch and sucrose metabolism 0 2 1 5 1 0 0.011597
Sphingolipid metabolism 0 4 1 5 0 0 0.013042
Cell cycle 17 0 1 0 0 0 0.014158
Carbohydrate digestion and absorption 0 2 1 5 1 0 0.014633
Proximal tubule bicarbonate reclamation 1 5 1 0 0 0 0.014947
Arginine and proline metabolism 1 5 0 4 0 0 0.01764
Glycosaminoglycan degradation 1 1 0 4 0 0 0.01764
ABC transporters 2 5 0 2 0 0 0.021963
Glycosphingolipid biosynthesis - globo series 0 1 0 4 0 0 0.023611
Steroid hormone biosynthesis 1 2 1 3 0 1 0.024807
Fructose and mannose metabolism 1 4 1 2 0 0 0.024807
Glycolysis / Gluconeogenesis 2 5 1 3 0 0 0.024807
Chemical carcinogenesis 1 6 0 2 0 0 0.024807
Glutathione metabolism 3 5 1 0 0 0 0.024807
Steroid biosynthesis 6 0 0 0 0 0 0.025842
Drug metabolism - cytochrome P450 1 6 0 1 0 0 0.025842
Complement and coagulation cascades 6 2 3 1 0 0 0.026353
p53 signaling pathway 6 2 3 0 0 0 0.026976
Glycine, serine and threonine metabolism 4 1 2 1 0 0 0.027354
Renin-angiotensin system 1 3 0 2 0 0 0.027354
Pyrimidine metabolism 10 1 2 0 0 0 0.03345
Amoebiasis 3 7 0 4 0 0 0.034505
Nitrogen metabolism 3 0 1 1 0 0 0.034505