Fig. 7

NF-κB was involved in NLRP3 inflammasome-induced liver fibrosis of mice infected with S. japonicum. Protein expression of NF-κB in liver tissues (a) and in primary KCs (c) isolated from model mice were detected via western blot. The expression of NF-κB protein was quantified. b NF-κB immunofluorescent co-staining with F4/80 (KCs marker) in liver tissues. The quantitative changes were measured by Image-Pro Plus 6.0. Data are mean ± SEM of 6 mice/group. ^aP < 0.05, ^bP < 0.05, ^bbP < 0.01 vs SJ; ^*P < 0.05, ^***P < 0.001 vs N. Abbreviations: N, control group; SJ, infected group; NS, no statistical significance. Scale-bars: b, 100 μm