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Table 1 Percentage of dogs testing amicrofilaremic

From: Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol

Treatment group Study day
0 28 56 84 112 140 168
Doxycycline (10 mg/kg) 0 25 50 75 87.5 87.5 100
Doxycycline (5 mg/kg) 0 12.5 25 75 87.5 100 100
Minocycline (10 mg/kg) 0 0 50 75 100 100 100
Minocycline (5 mg/kg) 0 12.5 37.5 87.5 100 100 100
  1. Notes: Thick smears and modified Knott tests were performed prior to initiation of treatment, every 7 days throughout tetracycline treatment, and monthly thereafter until the dog tested negative for the presence of heartworm antigen. All study dogs tested negative for the presence of circulating microfilariae by study day 168, 3 months after the last melarsomine injection. All dogs received six months of oral HeartgardĀ® Plus (ivermectin/pyrantel)