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Fig. 4 | Parasites & Vectors

Fig. 4

From: Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production

Fig. 4

Effects of selected hit compounds on S. mansoni adult worm pairs viability and egg production in vitro. a Viability curves of adult worm pairs treated with SmI-124, SmI-148, and SmI-558 at 5 (square) or 10 μM (triangle) concentrations. DMSO (circle) and trichostatin A (TSA) (diamond) treatments represent the negative and positive controls, respectively. b Total egg counts laid by pairs treated with a sub-lethal dose (5 μM) of the indicated compounds normalized to worm couples are shown. The mean data ± SEM of three independent experiments are shown. The levels of statistical significance are indicated above bars; *P < 0.05, **P < 0.01, Student’s t-test

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Parasites & Vectors

ISSN: 1756-3305

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