Drug | Concentration (μg/ml) | Average AUC ± SD | Kruskal-Wallis rank sum test | Spearman’s rank correlation | |||
---|---|---|---|---|---|---|---|
χ 2 | df | P-value | rho | P-value | |||
DMSO (0.1%) | 99.5 ± 0.4 | – | – | – | – | – | |
FLBZ | 0.05 | 90.9 ± 0.9 | 19.286 | 5 | 0.00170 | -0.946 | <0.0001 |
0.1 | 92.7 ± 0.6 | ||||||
0.5 | 84.8 ± 2.3 | ||||||
1 | 74.8 ± 0.7 | ||||||
10 | 58.7 ± 0.7 | ||||||
HFLBZ | 0.05 | 99.6 ± 0.3 | 17.662 | 5 | 0.00340 | -0.908 | <0.0001 |
0.1 | 98.7 ± 0.4 | ||||||
0.5 | 95.7 ± 0.7 | ||||||
1 | 90.8 ± 1.4 | ||||||
10 | 78.1 ± 0.5 | ||||||
RFLBZ | 0.05 | 91.7 ± 2.7 | 18.784 | 5 | 0.00211 | -0.950 | <0.0001 |
0.1 | 92.7 ± 0.8 | ||||||
0.5 | 89.7 ± 0.9 | ||||||
1 | 87.2 ± 0.6 | ||||||
10 | 85.7 ± 0.9 |