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Table 1 Relationship between average AUC and the concentrations of the drugs tested

From: Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents

Drug

Concentration (μg/ml)

Average AUC ± SD

Kruskal-Wallis rank sum test

Spearman’s rank correlation

χ 2

df

P-value

rho

P-value

DMSO (0.1%)

99.5 ± 0.4

–

–

–

–

–

FLBZ

0.05

90.9 ± 0.9

19.286

5

0.00170

-0.946

<0.0001

0.1

92.7 ± 0.6

0.5

84.8 ± 2.3

1

74.8 ± 0.7

10

58.7 ± 0.7

HFLBZ

0.05

99.6 ± 0.3

17.662

5

0.00340

-0.908

<0.0001

0.1

98.7 ± 0.4

0.5

95.7 ± 0.7

1

90.8 ± 1.4

10

78.1 ± 0.5

RFLBZ

0.05

91.7 ± 2.7

18.784

5

0.00211

-0.950

<0.0001

0.1

92.7 ± 0.8

0.5

89.7 ± 0.9

1

87.2 ± 0.6

10

85.7 ± 0.9

  1. Abbreviations: AUC area under the curve, DMSO dimethylsulfoxide, FLBZ flubendazole, HFLBZ hydrolysed flubendazole, RFLBZ reduced flubendazole, SD standard deviation