Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents

Table 4 Summary statistics of worm recovery in CcR3 KO mice within 30 days

Experimental groups	Statistics	Recovery time (days)				AUC (%)
Experimental groups	Statistics	5	10	15	20	AUC (%)
Control (n = 7)^a	Mean	31.1	21.5	8.8	16.5	23.9
	Geometric mean	22.4	11.8	4.2	7.1	21.3
	Median	35.5	14.5	5.5	12.0	20.8
	SD	18.05	26.1	9.6	19.6	11.9
10 mg/kg FLBZ (s.c., single dose, n = 7)^a	Mean	2.1	0	0	0	8.7
	Median	2.5	0	0	0	8.8
	Geometric mean	1.5	0	0	0	8.7
	SD	2.1	0	0	0	0.4
Mann-Whitney rank sum test	U	28	–	–	–	4
Mann-Whitney rank sum test	P-value	0.0156	–	–	–	0.01052

Abbreviations: AUC area under the curve, n number of animal per group, FLBZ flubendazole, – not computed, SD standard deviation
^aSeven animals were dissected at each time point except on days 10 and 20, where 5 were dissected

ISSN: 1756-3305