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Table 2 Worm burden reduction values obtained after treatment of hamsters harboring O. felineus with tribendimidine or praziquantel

From: A study of tribendimidine effects in vitro and in vivo on the liver fluke Opisthorchis felineus

 

Number of animals

Mean no. of worms ± SD

WBR (%)

Mean EPG ± SD

ERR (%)

Treatment of chronic infection (3 months)

 Control

13

33 ± 10

1863 ± 1006

 TBN, 400 mg/kg

5

7 ± 4

76

927 ± 620

51.0

 PZQ, 400 mg/kg

11

8 ± 5

77.2

nd

nd

Treatment of acute infection (1 month)

 Control1

5

19 ± 2

863 ± 279

 Control2

6

34 ± 9

nd

 TBN1, 400 mg/kg

5

2 ± 4

90

299 ± 244

65.4

 PZQ2, 400 mg/kg

7

8 ± 6

76.5

nd

nd

Treatment of acute infection (15 days)

 TBN1, 400 mg/kg

5

2 ± 2

90.7

463 ± 281

46.3

  1. Superscript numbers denote data relative to the corresponding control group
  2. Abbreviations: TBN, tribendimidine; PZQ, praziquantel; SD, standard deviation, WBR, worm burden reduction rate, EPG, eggs per gram of feces, ERR, egg reduction rates, nd, not determined