Days after inoculation | Number of mice demonstrating histopathological alterations in the | ||||||||
---|---|---|---|---|---|---|---|---|---|
Brain | Spleen | Liver | Kidneys | Lungs | Diaphragm | ||||
Multifocal encephalitis with perivascular cuffing of small lymphocytes | Multifocal lymphocytic encephalitis | Glial nodules | Multifocal extramedullar haematopoiesis | Extramedullar haematopoiesis | Multifocal mononuclear cell infiltration of cortical and medullary interstitium | Multifocal lymphocytic peribronchial inflitration | Thickening of serous membrane through mixed cell infiltration | Lymphocytic diaphragmitis | |
10 | 2/2 | 2/2 | 0/2 | 1/2 | 1/2 | 1/2 | 1/2 | 0/2 | 0/2 |
20 | 2/2 | 2/2 | 1/2 | 1/2 | 1/2 | 1/2 | 2/2 | 0/2 | 0/2 |
30 | 2/2 | 2/2 | 1/2 | 1/2 | 2/2 | 1/2 | 2/2 | 1/2 | 1/2 |
45 | 1/2 | 1/2 | 2/2 | 0/2 | 0/2 | 0/2 | 0/2 | 1/2 | 1/2 |
60 | 2/2 | 2/2 | 2/2 | 0/2 | 0/2 | 0/2 | 0/2 | 2/2 | 2/2 |