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Table 2 Study 1. Frequency of major histopathological changes recorded in the organs of mice inoculated with ~30 A. abstrusus third-stage larvae each by histological examination of half organs at intervals after inoculation (two mice per time point)

From: Mice as paratenic hosts of Aelurostrongylus abstrusus

Days after inoculation Number of mice demonstrating histopathological alterations in the
Brain Spleen Liver Kidneys Lungs Diaphragm
Multifocal encephalitis with perivascular cuffing of small lymphocytes Multifocal lymphocytic encephalitis Glial nodules Multifocal extramedullar haematopoiesis Extramedullar haematopoiesis Multifocal mononuclear cell infiltration of cortical and medullary interstitium Multifocal lymphocytic peribronchial inflitration Thickening of serous membrane through mixed cell infiltration Lymphocytic diaphragmitis
10 2/2 2/2 0/2 1/2 1/2 1/2 1/2 0/2 0/2
20 2/2 2/2 1/2 1/2 1/2 1/2 2/2 0/2 0/2
30 2/2 2/2 1/2 1/2 2/2 1/2 2/2 1/2 1/2
45 1/2 1/2 2/2 0/2 0/2 0/2 0/2 1/2 1/2
60 2/2 2/2 2/2 0/2 0/2 0/2 0/2 2/2 2/2