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Table 1 IC50 values of thymoquinone and diminazene aceturate evaluated for bovine Babesia and equine Babesia and Theileria parasites

From: Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites

Organism

IC50 (μM)a

Thymoquinone

Diminazene aceturate

B. bovis

35.41 ± 3.60

0.415 ± 0.07

B. bigemina

7.35 ± 0.17

0.209 ± 0.005

B. divergens

0.28 ± 0.016

0.12 ± 0.03

T. equi

74.05 ± 4.55

0.709 ± 0.047

B. caballi

67.33 ± 0.94

0.007 ± 0.0002

  1. aIC50 values for thymoquinone and diminazene aceturate were calculated on the fourth day based on the growth inhibitions determined using a fluorescence-based assay in three separate experiments. Each drug concentration was made in triplicate in each experiment, and the final obtained IC50 represents the mean and standard deviation of three separate experiments
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Parasites & Vectors

ISSN: 1756-3305

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