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Table 2 Statistical analysis of SbIII susceptibility assays on the intracellular amastigotes of wild type and GPI-14-overexpressor L. braziliensis clones

From: Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony

SbIII (μM)

Percentage of infected macrophagesa

No. of parasites per 100 macrophagesb

LbWT vs LbGPI14C4

LbWT vs LbGPI14C10

LbWT vs LbGPI14C4

LbWT vs LbGPI14C10

12.5

t(10) = 5.575, P = 0.0002

t(10) = 5.364, P = 0.0003

t(10) = 3.998, P = 0.0025

t(10) = 5.180, P = 0.0004

25

t(10) = 4.376, P = 0.0014

t(10) = 4.094, P = 0.0022

t(10) = 4.822, P = 0.0007

t(10) = 3.284, P = 0.0082

50

t(10) = 7.174, P < 0.0001

t(10) = 7.865, P < 0.0001

t(10) = 7.254, P < 0.0001

t(10) = 7.140, P < 0.0001

100

t(10) = 2.925, P = 0.0152

t(10) = 3.164, P = 0.0101

t(10) = 3.776, P = 0.0036

t(10) = 4.558, P = 0.0010

200

t(10) = 2.449, P = 0.0343

t(10) = 1.524, P = 0.1584

t(10) = 2.465, P = 0.0334

t(10) = 1.674, P = 0.1250

  1. aPairwise comparisons (Student’s t-test) (Fig. 2b)
  2. bPairwise comparisons (Student’s t-test) (Fig. 2c)