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Table 2 Statistical analysis of SbIII susceptibility assays on the intracellular amastigotes of wild type and GPI-14-overexpressor L. braziliensis clones

From: Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony

SbIII (μM) Percentage of infected macrophagesa No. of parasites per 100 macrophagesb
LbWT vs LbGPI14C4 LbWT vs LbGPI14C10 LbWT vs LbGPI14C4 LbWT vs LbGPI14C10
12.5 t(10) = 5.575, P = 0.0002 t(10) = 5.364, P = 0.0003 t(10) = 3.998, P = 0.0025 t(10) = 5.180, P = 0.0004
25 t(10) = 4.376, P = 0.0014 t(10) = 4.094, P = 0.0022 t(10) = 4.822, P = 0.0007 t(10) = 3.284, P = 0.0082
50 t(10) = 7.174, P < 0.0001 t(10) = 7.865, P < 0.0001 t(10) = 7.254, P < 0.0001 t(10) = 7.140, P < 0.0001
100 t(10) = 2.925, P = 0.0152 t(10) = 3.164, P = 0.0101 t(10) = 3.776, P = 0.0036 t(10) = 4.558, P = 0.0010
200 t(10) = 2.449, P = 0.0343 t(10) = 1.524, P = 0.1584 t(10) = 2.465, P = 0.0334 t(10) = 1.674, P = 0.1250
  1. aPairwise comparisons (Student’s t-test) (Fig. 2b)
  2. bPairwise comparisons (Student’s t-test) (Fig. 2c)