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Table 2 Summary of successful studies on captive wildlife with a post-treatment monitoring period

From: The treatment of sarcoptic mange in wildlife: a systematic review

Treated species and reference No. of animals treated Severitya Treatmentb Duration of post-treatment monitoring
Drug(s) administered Dose & delivery method No. of doses Treatment interval between doses
American black bear (Ursus americanus), Van Wick et al. (2018) [21] 1 Severe a) Fluralaner;
b) Lactated Ringer’s solution;
c) Hydrogenated iron
a) 44 mg/kg PO;
b) 40 ml/kg SC;
c) 10 mg/kg IM
a) 1;
b) 1;
c) 1
na 13 weeks
Mara (Dolichotis caviae), Kim et al. (2015) [25] 2/16 (i.e. clinically affected individuals) Moderate a) Amitraz;
b) Prednisolone
a) 0.025% wash;
b) 2 ml IM
a) 4;
b) 4
a) 7 days;
b) 7 days
 
16/16 (i.e. colony-wide treatment) Mild to moderate a) Ivermectin;
b) Prednisolone
a) 400 µg/kg SC;
b) 2 ml IM
a) 4;
b) 4
a) 7 days;
b) 7 days
104 weeks
Raccoon dog (Nyctereutes procyonoides), Kido et al. (2014) [27] 68 Moderate to severe Ivermectin 400 µg/kg SC 2 14 days 18 weeks on average
157 Moderate to severe a) Ivermectin;
b) Cephalexin;
c) Lactated Ringer’s solution
a) 400 µg/kg SC;
b) 20 mg/kg PO;
c) Intravenous
a) 3;
b) 14;
c) 1
a) 14 days;
b) 12 hours;
c) na
18 weeks on average
Southern hairy-nosed wombat (Lasiorhinus latrifrons), Ruykys et al. (2013) [24] 2/5 (i.e. captive wombats) Severe Ivermectin 200 µg/kg SC 1 na 7–10 weeks, depending on the animal
African buffalo (Syncerus caffer), Munang’Andu et al. (2010) [26] 77 Mild to severe Ivermectin 200 µg/kg SC 4 30 days 6 weeks
Roe deer (Capreolus capreolus), Menzano et al. (2008) [20] 3 Moderate to severe Ivermectin 300 µg/kg SC 3 15 days 52 weeks
Bare-nosed wombat (Vombatus ursinus), Skerratt et al. (2003) [28] 2/7 (i.e. Experiment one) Mild to severe a) Ivermectin;
b) Procaine penicillin;
c) Benzaine penicillin
a) 300 µg/kg SC;
b) 15 mg/kg IM;
c) 11 mg/kg IM
a) 3;
b) 1;
c) 1
a) 10 days;
b) na;
c) na
22 weeks
  7/7 (i.e. Experiment two) Mild to severe a) Ivermectin;
b) Procaine penicillin;
c) Benzaine penicillin
a) 300 µg/kg SC;
b) 15 mg/kg IM;
c) 11 mg/kg IM
a) 3;
b) 1;
c) 1
a) 10 days;
b) na;
c) na
8 weeks
  3/7 (i.e. wombats whose mange recurred in Experiment two) Mild Ivermectin 300 µg/kg SC 3 10 days 18 weeks
Iberian ibex (Capra pyrenaica), Leon-Vizcaino et al. (2001) [23] 3 Moderate Ivermectin 400 µg/kg SC 1 na 8 weeks
3 Moderate Ivermectin 400 µg/kg SC or superficial IM by rifle dart 1 na 8 weeks
3 Moderate Ivermectin 200 µg/kg SC 1 na 8 weeks
3 Severe Ivermectin 200 µg/kg SC 2 14 days 6 weeks
3 Severe Ivermectin 400 µg/kg SC 2 14 days 6 weeks
17 None to mild a) Phoxim;
b) Ivermectin
a) 500 mg/l topical spray;
b) 400 µg/kg SC
a) 1;
b) 1
na 45 weeks
32 Mild to moderate a) Phoxim;
b) Ivermectin
a) 500 mg/l topical spray;
b) 200–400 µg/kg SC or superficial IM by rifle dart
a) 1;
b) 3
a) na;
b) 14 days
45 weeks
Chamois (Rupricapra pyrenaica), Lavin et al. (2000) [51] 2 Mild to moderate Ivermectin 200 µg/kg SC 2 15 days 2 weeks
Red fox (Vulpes vulpes), Little et al. (1998) [52] 5 Severe Ivermectin 400 µg/kg SC 2 14 days 8–15 weeks, depending on the animal
  1. aSeverity of mange prior to treatment
  2. bAlphabetized bullet points indicate different medications delivered concurrently
  3. Abbreviation: na, not applicable