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Table 2 Irritant effect of DEET, permethrin, carvacrol, geraniol, cuminaldehyde and cinnamaldehyde on Anopheles gambiae from reference strains, the susceptible Kisumu strain (Kis), the pyrethroid-resistant strain KdrKis and the OP-resistant strain AcerKis

From: Insecticide resistance modifies mosquito response to DEET and natural repellents

Product

Concentration (µl/cm2)

Kis strainab

KdrKis strainab

AcerKis strainab

Permethrin

0.010

37.7 (25.0–50.4)

3.0 (0.0–7.9)*

10.1 (0.0–21.0) *

0.100

25.9 (13.8–38.0)

45.6 (33.7–57.4)

27.9 (16.7–39.1)

DEET

0.010

7.6 (0.0–15.5)

22.6 (11.3–33.8)

16.5 (7.3–25.7)

0.100

54.1 (42.6–65.7)

71.2 (62.1–80.3)

43.6 (32.1–55.2)

Carvacrol

0.001

50.0 (38.2–61.8)

0.1 (0.0–7.7)*

13.9 (5.2–22.7)*

0.014

84.3 (77.4–91.2)

45.3 (33.4–57.2)*

49.3 (37.2–61.5)*

Geraniol

0.002

16.5 (5.2–27.7)

24.8 (14.5–35.2)

19.6 (9.1–30.2)

0.023

45.9 (41.4–50.4)

73.9 (65.7–82.0)*

41.8 (30.4–53.3)

Cuminaldehyde

0.003

10.4 (1.1–19.6)

20.2 (9.5–31.0)

9.6 (1.9–17.2)

0.030

77.5 (69.4–85.6)

63.0 (53.0–73.0)

46.3 (35.2–57.5)*

Cinnamaldehyde

0.008

22.0 (12.3–31.7)

23.8 (12.7–34.9)

11.7 (1.4–21.9)

0.079

63.2 (52.9–73.4)

70.4 (60.6–80.3)

51.1 (38.4–63.8)

  1. aProportion of escaping mosquitoes in percentage corrected with the negative control to compare strains by pairs (confidence interval)
  2. bPairwise comparison of proportion was done using Fisher’s test with the Holm’s sequential Bonferroni correction method. Values in bold lettering are significantly different from the non-treated control. Values followed by an asterisk (*) are significantly different from the Kis strain