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Table 5 Risk of psychiatric disorders subgroup in the trichomoniasis patients treated with MTZ identified by using Cox regression

From: Infection with Trichomonas vaginalis increases the risk of psychiatric disorders in women: a nationwide population-based cohort study

Psychiatric disorder subgroup

Trichomoniasis and metronidazole (MTZ)

Competing risk in the model

Population

Event

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Overall

Without trichomoniasis

37,492

198

Ref.

  

Ref.

     

With trichomoniasis

9373

875

1.644

1.514–1.766

<0.001

      

 With trichomoniasis, without MTZ

6433

630

   

1.732

1.577–1.902

<0.001

Ref.

  

 With trichomoniasis, with MTZ

2940

245

   

1.458

1.271–1.672

<0.001

0.876

0.739–1.039

0.128

Depression

Without trichomoniasis

37,492

812

Ref.

  

Ref.

     

 With trichomoniasis

9373

371

1.675

1.474–1.904

<0.001

      

 With trichomoniasis, without MTZ

6433

266

   

1.865

1.613–2.156

<0.001

Ref.

  

With trichomoniasis, with MTZ

2940

105

   

1.335

1.083–1.647

0.007

0.639

0.493–0.829

0.001

Anxiety

Without trichomoniasis

37,492

553

Ref.

  

Ref.

     

With trichomoniasis

9373

294

2.011

1.738–2.327

<0.001

      

 With trichomoniasis, without MTZ

6433

231

   

2.120

1.807–2.486

<0.001

Ref.

  

 With trichomoniasis, with MTZ

2940

63

   

1.701

1.301–2.222

<0.001

0.948

0.692–1.300

0.741

Bipolar disorder

Without trichomoniasis

37,492

105

Ref.

  

Ref.

     

With trichomoniasis

9373

42

1.784

1.241–2.565

0.002

      

 With trichomoniasis, without MTZ

6433

35

   

2.219

1.497–3.287

<0.001

Ref.

  

 With trichomoniasis, with MTZ

2940

7

   

0.908

0.418–1.972

0.807

0.481

0.207–1.118

0.089

PTSD/ASD

Without trichomoniasis

37,492

42

Ref.

  

Ref.

     

With trichomoniasis

9373

7

0.792

0.354–1.772

0.570

      

 With trichomoniasis, without MTZ

6433

7

   

1.015

0.450–2.288

0.972

Ref.

  

 With trichomoniasis, with MTZ

2940

0

   

0.0001

–

0.963

0.0001

–

0.971

Schizophrenia

Without trichomoniasis

37,492

147

Ref.

  

Ref.

     

With trichomoniasis

9373

91

1.981

1.495–2.624

<0.001

      

 With trichomoniasis, without MTZ

6433

70

   

2.315

1.699–3.156

<0.001

Ref.

  

 With trichomoniasis, with MTZ

2940

21

   

1.352

0.838–2.180

0.216

0.690

0.385–1.237

0.212

Substance abuse

Without trichomoniasis

37,492

91

Ref.

  

Ref.

     

With trichomoniasis

9373

84

2.794

2.035–3.834

<0.001

      

 With trichomoniasis, without MTZ

6433

56

   

2.97

2.073–4.256

<0.001

Ref.

  

 With trichomoniasis, with MTZ

2940

28

   

2.516

1.615–3.919

<0.001

0.978

0.428–2.686

0.057

Other psychiatric disorders

Without trichomoniasis

37,492

56

Ref.

  

Ref.

     

With trichomoniasis

9373

77

1.098

0.872–1.211

0.184

      

 With trichomoniasis, without MTZ

6433

49

   

1.012

0.642–1.19

0.872

Ref.

  

 With trichomoniasis, with MTZ

2940

28

   

1.584

1.104–1.984

0.001

1.971

1.169–3.322

0.011

  1. Abbreviations: MTZ, metronidazole; Adjusted HR, adjusted hazard ratio (adjusted for the variables listed in Table 1); CI, confidence interval; PTSD, post-traumatic stress disorder; ASD, acute stress disorder; Ref., reference
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