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Table 2 Spearman’s correlation between age, IgD concentration, LSA IFN-γ concentration and serology by groups studied

From: Total serum IgD from healthy and sick dogs with leishmaniosis

 

Spearman’s rs (P-value)

IgD concentration (ng/ml)

L. infantum antibodies (EU)

All dogs (n = 147)

 Age (months)

0.0220 (0.8096)

0.2024 (0.0254)*

 IgD concentration (ng/ml)

1

0.0307 (0.7120)

 L. infantum antibodies (EU)

0.0307 (0.7120)

1

 LSA IFN-γ concentration (pg/ml)

0.0438 (0.5983)

0.1742 (0.0348)*

All healthy dogs (n = 103)

 Age (months)

0.1664 (0.1401)

0.0713 (0.5300)

 IgD concentration (ng/ml)

1

0.0067 (0.9468)

 L. infantum antibodies (EU)

0.0067 (0.9468)

1

 LSA IFN-γ concentration (pg/ml)

0.0481 (0.6297)

0.4872 (< 0.0001)*

Sick dogs (n = 44)

 Age (months)

-0.2665 (0.0881)

0.1104 (0.4862)

 IgD concentration (ng/ml)

1

0.0297 (0.8483)

 L. infantum antibodies (EU)

0.0297 (0.8483)

1

 LSA IFN-γ concentration (pg/ml)

0.0549 (0.7235)

-0.3233 (0.0323)*

Control healthy dogs (non-infected) (n = 40)

 Age (months)

0.1206 (0.5038)

0.0609 (0.7366)

 IgD concentration (ng/ml)

1

-0.1898 (0.2408)

 L. infantum antibodies (EU)

-0.1898 (0.2408)

1

 LSA IFN-γ concentration (pg/ml)

-0.0104 (0.9493)

-0.2315 (0.1506)

Control healthy dogs (infected) (n = 63)

 Age (months)

0.2145 (0.1476)

0.0735 (0.6235)

 IgD concentration (ng/ml)

1

0.0692 (0.5899)

 L. infantum antibodies (EU)

0.0692 (0.5899)

1

 LSA IFN-γ concentration (pg/ml)

0.0124 (0.9232)

0.4212 (0.0006)*

  1. *Statistically significant P-values
  2. Abbreviations: LSA, Leishmania soluble antigen; ConA, concanavalin A; IFN-γ, interferon gamma; IgD, immunoglobulin D; EU, ELISA units