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Table 2 Spearman’s correlation between age, IgD concentration, LSA IFN-γ concentration and serology by groups studied

From: Total serum IgD from healthy and sick dogs with leishmaniosis

  Spearman’s rs (P-value)
IgD concentration (ng/ml) L. infantum antibodies (EU)
All dogs (n = 147)
 Age (months) 0.0220 (0.8096) 0.2024 (0.0254)*
 IgD concentration (ng/ml) 1 0.0307 (0.7120)
 L. infantum antibodies (EU) 0.0307 (0.7120) 1
 LSA IFN-γ concentration (pg/ml) 0.0438 (0.5983) 0.1742 (0.0348)*
All healthy dogs (n = 103)
 Age (months) 0.1664 (0.1401) 0.0713 (0.5300)
 IgD concentration (ng/ml) 1 0.0067 (0.9468)
 L. infantum antibodies (EU) 0.0067 (0.9468) 1
 LSA IFN-γ concentration (pg/ml) 0.0481 (0.6297) 0.4872 (< 0.0001)*
Sick dogs (n = 44)
 Age (months) -0.2665 (0.0881) 0.1104 (0.4862)
 IgD concentration (ng/ml) 1 0.0297 (0.8483)
 L. infantum antibodies (EU) 0.0297 (0.8483) 1
 LSA IFN-γ concentration (pg/ml) 0.0549 (0.7235) -0.3233 (0.0323)*
Control healthy dogs (non-infected) (n = 40)
 Age (months) 0.1206 (0.5038) 0.0609 (0.7366)
 IgD concentration (ng/ml) 1 -0.1898 (0.2408)
 L. infantum antibodies (EU) -0.1898 (0.2408) 1
 LSA IFN-γ concentration (pg/ml) -0.0104 (0.9493) -0.2315 (0.1506)
Control healthy dogs (infected) (n = 63)
 Age (months) 0.2145 (0.1476) 0.0735 (0.6235)
 IgD concentration (ng/ml) 1 0.0692 (0.5899)
 L. infantum antibodies (EU) 0.0692 (0.5899) 1
 LSA IFN-γ concentration (pg/ml) 0.0124 (0.9232) 0.4212 (0.0006)*
  1. *Statistically significant P-values
  2. Abbreviations: LSA, Leishmania soluble antigen; ConA, concanavalin A; IFN-γ, interferon gamma; IgD, immunoglobulin D; EU, ELISA units