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Table 1 Summary of pharmacokinetic data in blood (plasma plus red blood cells) for pigs treated with 0.6 mg/kg of ivermectin or moxidectin

From: Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Delivery method

Ivermectin

Moxidectin

Pour-ona

Orala

Subcutaneousa

Subcutaneous

AUC0-t (ng/ml∙d)

4.4 (3.4, 5.4)

48.3 (47.7, 52.8)

246.9 (218.3, 275.6)

686.7 (623.9–749.4)

AUC0-∞ (ng/ml∙d)

5.9 (5.9, 5.9)

48.5 (43.9, 53.0)

256.6 (236.1, 277.0)

786.0 (745.0–827.0)

Cmax (ng/ml)

0.9 (0.5, 1.2)

19.9 (19.1, 20.7)

34.1 (26.4, 41.7)

83.7 (87.5–79.9)

Tmax (d)

3.0 (3.0, 3.0)

1.0 (1.0, 1.0)

2.0 (1.0, 3.0)

0.5 (0.5–0.5)

t1/2 (d)

6.1 (8.7, 3.4)

1.7 (1.8, 1.7)

4.0 (5.4, 2.6)

19.5 (21.5–17.4)b

  1. aData are presented as a “Mean (Pig 1, Pig 2)”
  2. bThe moxidectin terminal half-life in blood may not be appropriate as the time interval the drug was measured over was not sufficient (< 2t1/2). Therefore, caution is required when interpreting the terminal half-life for moxidectin
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Parasites & Vectors

ISSN: 1756-3305

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