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Table 1 Summary of pharmacokinetic data in blood (plasma plus red blood cells) for pigs treated with 0.6 mg/kg of ivermectin or moxidectin

From: Treatment of pigs with endectocides as a complementary tool for combating malaria transmission by Anopheles farauti (s.s.) in Papua New Guinea

Delivery method Ivermectin Moxidectin
Pour-ona Orala Subcutaneousa Subcutaneous
AUC0-t (ng/ml∙d) 4.4 (3.4, 5.4) 48.3 (47.7, 52.8) 246.9 (218.3, 275.6) 686.7 (623.9–749.4)
AUC0- (ng/ml∙d) 5.9 (5.9, 5.9) 48.5 (43.9, 53.0) 256.6 (236.1, 277.0) 786.0 (745.0–827.0)
Cmax (ng/ml) 0.9 (0.5, 1.2) 19.9 (19.1, 20.7) 34.1 (26.4, 41.7) 83.7 (87.5–79.9)
Tmax (d) 3.0 (3.0, 3.0) 1.0 (1.0, 1.0) 2.0 (1.0, 3.0) 0.5 (0.5–0.5)
t1/2 (d) 6.1 (8.7, 3.4) 1.7 (1.8, 1.7) 4.0 (5.4, 2.6) 19.5 (21.5–17.4)b
  1. aData are presented as a “Mean (Pig 1, Pig 2)”
  2. bThe moxidectin terminal half-life in blood may not be appropriate as the time interval the drug was measured over was not sufficient (< 2t1/2). Therefore, caution is required when interpreting the terminal half-life for moxidectin