Table 2 Immune system pathways predicted by Reactome 3.5 analysis to be stimulated by proteins present in ESP, immature and mature eggs

Cytokine signalling in immune response

Interferon signalling: Antiviral mechanism

–

–

Signalling by Interleukins: IL1, IL3, IL5, GM-CFS, IL4, IL13

–

–

TNF alpha non-canonical NF-Kappaβ pathway

–

–

Innate immune system

–

Toll-like receptor cascade: Trafficking and processing of endosomal TLR

–

Neutrophil degranulation

Neutrophil degranulation

Neutrophil degranulation

Fc gamma receptor (FCGR) dependent phagocytosis

–

–

Fc epsilon receptor (FCERI) signalling; Toll-like receptor cascade

–

–

C-type lectin receptors (CLR’s): CLEC7A (Dectin-1)

–

–

Nucleotide-Binding domain, leucine rich repeat containing receptor (NLR) signalling pathways

–

–

DDX58/IFIHI mediated induction of IFN alpha/beta pathways

–

–

Cytosolic sensors of pathogens associated DNA

–

–

Adaptive immune system

MHC class II antigen presentation

MHC class II antigen presentation

MHC class II antigen presentation

RAP-1 signalling

RAP-1 signalling

–

MHC class I mediated antigen processing and presentation

–

–

Signalling by the B cell receptor

–

–

TRL signalling

–

–