Fig. 2

Correlation between responses to drug treatment and CL endemic regions (a), and development of secondary infections (SI) and treatment response (b). a Distribution by region of 104 patients with L. major or L. tropica infections confirmed by culture, PCR-RFLP or clinical features. Patients from the Central region (exclusively infected with L. major) had a significantly higher response (healing; P = 0.001, Fisher’s exact test) to the first line of treatment compared to other CL-endemic regions studied. In addition, patients from the Eastern region, responded significantly favorably (P = 0.001; Fisher’s exact test) to the first course of SSG compared to those from both Northwest and Southwest regions. b Data for 96 patients with L. major (n = 75) or L. tropica (n = 21) infections confirmed by culture or PCR-RFLP. A significant P = 0.0002 (Chi-square test) response to first line of treatment was observed only in L. major patients that had developed SI. However, there were no significant differences in L. tropica patients with or without SI. Abbreviations: SI, presence of secondary infections; No SI, absence of secondary infections