Skip to main content

Advertisement

Table 2 Correlation between location of CL lesions and patient response to drug treatment. Data for 96 patients with L. major or L. tropica infections confirmed by culture or PCR-RFLP

From: Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

Lesion location % Patients responding to drug treatment (healing)
1st line (Azoles/fusidic acid) 2nd line (SSG) 1st course 2nd line (SSG) 2nd course Unresponsive casesa P-valueb
Head, neck or hand 41 (n = 13) 37 (n = 12) 5 (n = 2) 16 (n = 15) 0.0192 (n = 32)
Arms 32 (n = 6) 0 (n = 0) 21 (n = 4) 47 (n = 9) 0.2 (n = 19)
Trunk, legs or feet 32 (n = 6) 63 (n = 12) 0 (n = 0) 5c (n = 1) 0.02 (n = 19)
Face, nose or ear 10 (n = 1) 20d (n = 2) 20 (n = 2) 50e (n = 5) 0.5 (n = 10)
Disseminated (whole body) 13 (n = 2) 31 (n = 5) 13 (n = 2) 43f (n = 7) 0.7 (n = 16)
  1. a85% of patients that did not respond to drug treatment were infected with L. tropica
  2. bFisher’s exact test
  3. cUlcerated L. tropica cases with secondary infection
  4. dAll cases were L. major patients with apparent secondary infections
  5. eCases with satellite lesions
  6. fCases with multiple lesions receiving more than two courses of stibogluconate (SSG)