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Table 3 Mean IC50 values (µg/ml) after 72 hours drug exposure on L3 and adult stages of A. ceylanicum, N. americanus and T. muris of emodepside compared to the ones of albendazole, levamisole and pyrantel pamoate

From: Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections

Species Mean IC50 (µg/ml) after 72 hours of drug incubation
Emodepside Albendazolea Levamisole-HCla Pyrantel pamoatea
T. muris (L1) after 24 h 4.18    
T. muris (L3) ≥ 200 33.1 95.5
T. muris (adults) 0.022 ≥ 200 16.5 34.1
A. ceylanicum (L3) 0.28 32.40 1.60 90.9
A. ceylanicum (adults) 0.0027 ≥ 100 ≥ 100 ≥ 100
N. americanus (L3) 0.090 ≥ 100 0.50 2.0
N. americanus (adults) 0.0024 ≥ 100 13.40 7.6
  1. aAll values for this drug are taken from the study of Tritten et al. [36]