Table 3 Mean IC50 values (µg/ml) after 72 hours drug exposure on L3 and adult stages of A. ceylanicum, N. americanus and T. muris of emodepside compared to the ones of albendazole, levamisole and pyrantel pamoate
Species | Mean IC50 (µg/ml) after 72 hours of drug incubation | |||
|---|---|---|---|---|
Emodepside | Albendazolea | Levamisole-HCla | Pyrantel pamoatea | |
T. muris (L1) after 24 h | 4.18 | |||
T. muris (L3) | – | ≥ 200 | 33.1 | 95.5 |
T. muris (adults) | 0.022 | ≥ 200 | 16.5 | 34.1 |
A. ceylanicum (L3) | 0.28 | 32.40 | 1.60 | 90.9 |
A. ceylanicum (adults) | 0.0027 | ≥ 100 | ≥ 100 | ≥ 100 |
N. americanus (L3) | 0.090 | ≥ 100 | 0.50 | 2.0 |
N. americanus (adults) | 0.0024 | ≥ 100 | 13.40 | 7.6 |