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Fig. 2 | Parasites & Vectors

Fig. 2

From: Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

Fig. 2

Venn diagram showing the number of transcripts upregulated and downregulated in human THP-1 MΦ cells. a Total number of commonly or differentially expressed gene transcripts in differentiated THP-1 macrophages. b Number of gene transcripts of the drug transporter pathway. c Number of gene transcripts of the oxidative stress pathway. THP-1 MΦ cells infected with Trypanosoma cruzi CL Brener strain (yellow circles), THP-1 MΦ cells treated with benznidazole (dark blue circles), THP-1 MΦ cells infected with T. cruzi CL Brener strain and then treated with benznidazole (red circles), THP-1 MΦ cells infected with T. cruzi Colombiana strain (black circles), or THP-1 MΦ cells infected with T. cruzi Colombiana strain and then treated with benznidazole (pink circles). Upregulated genes are indicated by up arrows, and downregulated genes are indicated by down arrows in the different groups. The number of gene transcripts in the THP-1 MΦ cells corresponds to the mean of three independent experiments

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