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Table 1 The effect of benznidazole treatment on intracellular amastigotes of sensitive (CL Brener) and resistant (Colombiana) Trypanosoma cruzi strains in THP-1 macrophages

From: Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole

T. cruzi strain

IC50 (95% CI) BZ (μM)

Resistance indexa

CL Brener

3.2 (2.47–4.12)

na

Colombiana

9.01 (5.67–14.32)

2.82

  1. aResistance index was calculated by the ratio of the IC50 value for the T. cruzi naturally benznidazole-resistant (Colombiana) and the sensitive (CL Brener) strains
  2. Abbreviation: na, not applicable
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Parasites & Vectors

ISSN: 1756-3305

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