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Fig. 5 | Parasites & Vectors

Fig. 5

From: Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

Fig. 5

Neutrophil numbers in the spleen correlate positively with the adult worm burden and microfilariae load. Total number of spleen cells (a, b) and neutrophils (c, d) in IL-4R−/−, dblGATA, IL-5−/−, IL-4R−/−/IL-5−/− mice and wildtype (WT) controls 71 and 119 days post-L. sigmodontis-infection. Spearman correlation of the total neutrophil spleen cell numbers and peripheral blood microfilariae (MF) counts (e, f) and adult worm burden (g, h) at 71 and 119 days post-L. sigmodontis-infection in IL-4R−/− (green dots), dblGATA (red dots), IL-5−/− (blue dots), IL-4R−/−/IL-5−/− (orange dots) mice and wildtype controls (black dots). Results are shown as medians (ad) and Spearman correlation (eh). Differences were analyzed for statistical significance using the one-way ANOVA followed by Dunnett’s test (bd) and Kruskal–Wallis test followed by Dunn’s multiple comparison test (a). *P < 0.05, **P < 0.01, ***P < 0.001. Data in a, c, e, g are pooled from two independent experiments at 71 dpi with 10–16 mice per group. Remaining panels (b, d, f, h) are from one experiment at 119 dpi with 6–10 mice per group

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