Efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto® Plus) in cats following repeated experimental challenge with a field isolate of Ctenocephalides felis

Table 2 Between-group comparison of geometric mean flea counts from cats in an untreated control group, a group treated topically on Days 0, 28 and 56 with fipronil and (S)-methoprene, and a group treated topically on Day 0 with fluralaner plus moxidectin

Study day	Fipronil and (S)-methoprene vs control				Fluralaner plus moxidectin vs control				Fluralaner plus moxidectin vs fipronil and (S)-methoprene
	t-value	P-value	% Efficacy		t-value	P-value	% Efficacy		t-value	P-value
	t-value	P-value	GM	AM	t-value	P-value	GM	AM	t-value	P-value
2	t₍₂₇₎ = 3.3	0.003	48.7	38.0	t₍₂₇₎ = 21.1	<0.001	100	100	t₍₂₇₎ = −17.9	<0.001
9	t₍₁₈₎ = 4.6	<0.001	62.5	53.6	t₍₁₈₎ = 20.7	<0.001	100	100	t₍₁₈₎ = −16.1	<0.001
16	t₍₁₈₎ = 6.5	<0.001	65.6	60.8	t₍₁₈₎ = 27.2	<0.001	100	100	t₍₁₈₎ = −20.7	<0.001
30	t₍₁₈₎ = 3.5	0.003	59.6	49.4	t₍₁₈₎ = 16.6	<0.001	100	100	t₍₁₈₎ = −13.1	<0.001
44	t₍₁₈₎ = 5.3	<0.001	63.9	59.0	t₍₁₈₎ = 22.4	<0.001	100	100	t₍₁₈₎ = −17.1	<0.001
58	t₍₁₈₎ = 4.2	<0.001	44.3	43.9	t₍₁₈₎ = 28.8	<0.001	99.7	99.5	t₍₁₈₎ = −24.5	<0.001
72	t₍₂₇₎ = 5.5	<0.001	60.5	57.6	t₍₂₇₎ = 25.2	<0.001	100	100	t₍₂₇₎ = −19.8	<0.001
79	t₍₁₈₎ = 4.7	<0.001	48.1	46.2	t₍₁₈₎ = 30.2	<0.001	100	100	t₍₁₈₎ = −25.5	<0.001
86	t₍₂₇₎ = 3.3	<0.001	48.8	41.3	t₍₂₇₎ = 21.2	<0.001	100	100	t₍₂₇₎ = −17.9	<0.001
93	t₍₂₇₎ = 2.1	0.041	30.6	26.7	t₍₂₇₎ = 24.7	<0.001	100	100	t₍₂₇₎ = −22.5	<0.001

ISSN: 1756-3305