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Table 2 Between-group comparison of geometric mean flea counts from cats in an untreated control group, a group treated topically on Days 0, 28 and 56 with fipronil and (S)-methoprene, and a group treated topically on Day 0 with fluralaner plus moxidectin

From: Efficacy of a spot-on combination of fluralaner plus moxidectin (Bravecto® Plus) in cats following repeated experimental challenge with a field isolate of Ctenocephalides felis

Study day Fipronil and (S)-methoprene vs control Fluralaner plus moxidectin vs control Fluralaner plus moxidectin vs fipronil and (S)-methoprene
t-value P-value % Efficacy t-value P-value % Efficacy t-value P-value
GM AM GM AM
2 t(27) = 3.3 0.003 48.7 38.0 t(27) = 21.1 <0.001 100 100 t(27) = −17.9 <0.001
9 t(18) = 4.6 <0.001 62.5 53.6 t(18) = 20.7 <0.001 100 100 t(18) = −16.1 <0.001
16 t(18) = 6.5 <0.001 65.6 60.8 t(18) = 27.2 <0.001 100 100 t(18) = −20.7 <0.001
30 t(18) = 3.5 0.003 59.6 49.4 t(18) = 16.6 <0.001 100 100 t(18) = −13.1 <0.001
44 t(18) = 5.3 <0.001 63.9 59.0 t(18) = 22.4 <0.001 100 100 t(18) = −17.1 <0.001
58 t(18) = 4.2 <0.001 44.3 43.9 t(18) = 28.8 <0.001 99.7 99.5 t(18) = −24.5 <0.001
72 t(27) = 5.5 <0.001 60.5 57.6 t(27) = 25.2 <0.001 100 100 t(27) = −19.8 <0.001
79 t(18) = 4.7 <0.001 48.1 46.2 t(18) = 30.2 <0.001 100 100 t(18) = −25.5 <0.001
86 t(27) = 3.3 <0.001 48.8 41.3 t(27) = 21.2 <0.001 100 100 t(27) = −17.9 <0.001
93 t(27) = 2.1 0.041 30.6 26.7 t(27) = 24.7 <0.001 100 100 t(27) = −22.5 <0.001
  1. Abbreviations: GM, geometric mean; AM, arithmetic mean