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Table 4 Comparison of the results of trials with the same design but different infection days for bacteriological results

From: Efficacy of injectable toltrazuril-iron combination product and oral toltrazuril against early experimental infection of suckling piglets with Cystoisospora suis

Bacteriology (bacterial load and virulence factors)

 

E. coli (virulence factors)

Cl. perfringens (type; toxin)

Day of infection

1st dol

3rd dol

1st dol

3rd dol

Litters 4 days post-infection

 

++ − +++ a [fimH; iucD (2 litters)]

++ - +++a [fimH, papC, iucD, cnf1]

+ [A, beta 2]

+++ [A, beta 2]

Individual piglets (1st dol: n = 1+1, 3rd dol: n = 7)

Diarrhoeic piglet(s), toltrazuril treated

(+) [fimH; iucD]

++ - +++a [fimH, papC, iucD, cnf1]

Negative

+ − +++ [A, beta 2]

Matched healthy control

(+) [fimH]

Not done

Negative

Not done

Sows ante partum

 

++ − +++a [fimH, papC, astA, iucD, cnf1]

Not done

Negative

Not done

  1. aHaemolytic growth
  2. Abbreviations: AF, autofluorescence; MM, McMaster; OpG, oocysts per gram of faeces; FS, faecal score; dol, day of life