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Fig. 4 | Parasites & Vectors

Fig. 4

From: Role of the lipoxin A4 receptor in the development of neutrophil extracellular traps in Leishmania infantum infection

Fig. 4

Comparison of extracellular dsDNA among the experimental groups. Purified neutrophils pre-treated with or without the antagonist (Boc) or the agonist (LXA4) were exposed to L. infantum promastigotes for 5 h at 37 °C. Extracellular dsDNA in the culture supernatant of the experimental groups were quantified and compared to assess the NETs production. The differences were analyzed using one-way ANOVA, then LSD was applied in the following two groups’ comparison. *P < 0.05, **P < 0.01, ***P < 0.001. Abbreviations: Neu: control group of untreated neutrophils; Neu+Boc+Leish, Boc-pretreated neutrophils stimulated by L. infantum promastigotes; Neu+Leish, untreated neutrophils stimulated by L. infantum promastigotes; Neu+LXA4, untreated neutrophils stimulated by LXA4; Neu+LXA4+Leish, LXA4-pretreated neutrophils stimulated by promastigotes; Neu+Boc+LXA4, Boc-pretreated neutrophils stimulated by LXA4

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