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Fig. 2 | Parasites & Vectors

Fig. 2

From: Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33/ST2 expression

Fig. 2

tTG deletion alleviates the severity of Sj-induced hepatic fibrosis. Wild-type (WT) and tTG deficient (tTG-/-) mice were infected with 20 ± 3 cercariae of Sj for 0, 6 and 8 weeks. a Typical Sj single egg granuloma stained by Sirius red (200×, scale-bar: 50 μm) is shown on the left panel. The percentage of morphometric collagen areas around Sj single egg was calculated and is shown on the right panel (Mann-Whitney U-test, **P = 0.001, *P = 0.0492). b The protein expression levels of tTG and Col1 in mice liver homogenates detected by Western blotting are displayed on the left panel, and semi-quantitative analysis is shown on the right panel. GAPDH was used as loading control. c The average Sj egg numbers present in each liver section is shown. Data are presented as the mean ± SD from approximately three to six mice per group. All in vitro experiments were performed twice or thrice. Red arrows indicate the Sj eggs (t-test, ns)

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